What was studied? We wanted to see whether having pharmacists closely involved in cancer care improves medication safety and reduces severe side effects for patients with gynecologic cancers (like ovarian or uterine cancer) during chemotherapy. How was the study done? Who participated? Patients receiving chemotherapy at Peking University First Hospital's Gynecologic Oncology Ward (September 2022-September 2024). Two groups compared: Standard care group: Pharmacists provided routine pharmaceutical services. Full pharmacy care group: Pharmacists provided ongoing support, including: Checking medications for safety. Teaching patients how to manage side effects. Answering questions about drugs. Helping manage reactions like nausea or low white blood cells. What was measured? Severe side effects (e.g., extreme nausea, appetite loss), how well doctors prescribed and monitored medications to boost white blood cells, and unplanned hospital stays. Key findings: Patients with full pharmacy care had: Fewer severe side effects: Less extreme nausea, appetite loss, and dangerously low white blood cell counts. Better management of blood cell-boosting medications: Doctors followed guidelines more closely, and patients received proper monitoring. Fewer unplanned hospital visits: Likely due to better side effect prevention and early intervention. Why does this matter? For patients: Pharmacist support during chemotherapy may help you avoid severe side effects and reduce unexpected hospital stays. For families: Knowing pharmacists are actively involved can provide reassurance about your loved one's medication safety. For healthcare teams: Structured pharmacist collaboration improves adherence to treatment guidelines and patient outcomes. Takeaway: Full pharmacy care throughout chemotherapy helps protect patients' safety, reduces severe reactions, and supports smoother treatment journeys.
Study Type
OBSERVATIONAL
Enrollment
629
The intervention group received comprehensive pharmaceutical care in addition to standard care. For first-cycle patients, oncology pharmacists conducted patient education, informing them about potential chemotherapy-induced adverse reactions and corresponding management strategies. Patients were instructed on the proper use of antiemetic medications, the recommended frequency of blood routine tests, and the appropriate timing, dosing, and administration of granulocyte colony-stimulating factor (G-CSF) and thrombopoietic agents. A QR code for oncology pharmacist consultation was provided to enable patients to seek advice on medication-related issues encountered outside the hospital.
The control group received standard care: After the doctor issues the chemotherapy order, the oncology pharmacist only reviews the order to ensure that the chemotherapy regimen and pretreatment regimen during the study are consistent with those of the experimental group. No other interventions are performed.
Peking University First Hospital
Beijing, Beijing Municipality, China
Degree of myelosuppression
Time frame: From enrollment to the end of treatment at 3 weeks
Degree of adverse gastrointestinal reactions
Time frame: From enrollment to the end of treatment at 3 weeks
Readmission rate
Time frame: From enrollment to the end of treatment at 3 weeks
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