(I) AI Model for Diagnosing Lymph Node Metastasis We developed an AI model to help diagnose whether a single lymph node in nasopharyngeal cancer has spread. The model uses MRI images of the lymph node and the area around it. It includes: 1.Automatically identifying the lymph nodes and the primary tumor. 2.Analyzing MRI images of the lymph node and surrounding area. 3.Using MRI scans before and after chemotherapy to track changes in the lymph node. (II) AI Model for Predicting Lymph Node Metastasis We created an AI model that predicts whether a lymph node in a specific area has cancer. This model uses a combination of the primary tumor's pathology and MRI images of both the tumor and lymph node. It also tracks changes in the lymph node over time. The model includes: 1.Analyzing the tumor's pathology to identify specific lymphatic structures. 2.Using MRI scans to predict the likelihood of metastasis in a single lymph node. 3.Examining MRI scans before and after chemotherapy to help determine if the lymph node has metastasized. (III) Verifying and Analyzing the Benefits of the AI Model We are testing the AI model to see how well it works and its potential benefits, including: 1.Checking if the AI can correct past diagnoses of recurrent lymph nodes in nasopharyngeal cancer, which could help guide treatment plans for radiotherapy. 2.Testing the model using biopsy results from head and neck cancer patients to see if it can accurately detect negative lymph nodes. 3.Running clinical trials to test the AI model's safety and effectiveness in guiding radiation treatment for upper neck and single lymph node areas in nasopharyngeal cancer. 4.Analyzing the economic benefits of using the AI model in radiation treatment for nasopharyngeal cancer.
(I) AI Model for Assisting Diagnosis of Lymph Node Metastasis in Nasopharyngeal Carcinoma Based on MRI Features of the Lymph Node and Surrounding 3mm Area. An AI model is developed to assist in diagnosing whether a single lymph node in nasopharyngeal carcinoma has metastasized, based on the MRI features of the lymph node itself and its surrounding 3mm area. Specifically, the model includes: 1.Automatic segmentation of the lymph node and primary lesion using a semi-supervised AI model. 2.Construction of a single dual-view AI model based on baseline MRI features of the lymph node itself and its surrounding 3mm area. 3.Development of a dual-time series dual-view AI model based on MRI features of the lymph nodes before and after induction chemotherapy. (II) Multimodal AI Model for Predicting Lymph Node Metastasis. A multimodal AI model is constructed to predict metastasis of a single station lymph node and diagnose lymph node metastasis "from surface to point." This is based on pathological features of the nasopharyngeal primary lesion, MRI images, lymph node location, and other factors. Specifically, the model includes: 1.Construction of an AI model based on H\&E stained digital pathology of the primary lesion to extract features of the tertiary lymphatic structure. 2.Development of a multimodal AI model integrating pathological features of the nasopharyngeal primary lesion and baseline MRI images of both the primary lesion and lymph node to predict the probability of lymph node metastasis in a single station. 3.Construction of a single or dual-time series multimodal AI model using the probability of lymph node metastasis and baseline MRI or two MRI scans before and after induction chemotherapy to diagnose whether a single lymph node in the station has metastasized. (III) Verification and Economic Benefit Analysis of AI Models. The AI models are subjected to thorough verification and economic benefit analysis. Specifically, the process includes: 1.Retrospective correction of historical diagnoses of in situ recurrent lymph nodes in nasopharyngeal carcinoma patients using the AI model to verify its potential benefits in guiding prescription doses for single lymph node radiotherapy. 2.Validation of the AI model using pathological results from lymph node dissection in head and neck squamous cell carcinoma patients to assess the detection rate of clinically diagnosed negative lymph nodes. 3.Prospective clinical trials to evaluate the effectiveness and safety of the AI model in guiding prescription doses for upper neck radiotherapy and single lymph node radiotherapy in nasopharyngeal carcinoma patients. 4.Economic benefit analysis to illustrate the economic value of the AI model in guiding upper neck radiotherapy for nasopharyngeal carcinoma.
Study Type
OBSERVATIONAL
Enrollment
500
Department of Radiation Oncology, Sun Yat-sen University Cancer Center
Guangzhou, Guangdong, China
RECRUITINGAUC
AUC (Area Under the Curve) refers to the area under a performance curve, typically the ROC (Receiver Operating Characteristic) curve or PR (Precision-Recall) curve, that is used to evaluate the performance of a classification model. It is a single scalar value that provides an aggregate measure of a model's ability to distinguish between classes (e.g., positive and negative samples).
Time frame: through study completion, an average of 2 year
Sensitivity and Specificity
Sensitivity and Specificity are fundamental metrics used to evaluate the performance of a classification model, especially in medical diagnostics, machine learning, and statistics. These metrics are used to measure how well a model can correctly identify positive and negative cases.
Time frame: through study completion, an average of 2 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.