Study to Evaluate the Efficacy and Safety of AHB-137 in Treatment-naive Participants With Chronic Hepatitis B (CHB)

Inclusion Criteria: * Participants voluntarily participate in the study, and sign the Informed Consent Form (ICF) prior to screening, able to complete the study according to the protocol; * Male or female participants aged 18-65 years old (including the boundary value) at the time of signing the ICF; * Male participants weighed higher than 50 kg and female participants weighted higher than 50 kg, Body Mass Index (BMI) between 18 to 32 kg/m\^2(inclusive); * Participants with positive HBsAg or HBV DNA greater than or equal to (≥) 6 months prior to screening and has not received antiviral treatment with interferon or NAs ; * At screening, ALT\<3×upper limit of normal (ULN); * Use effective contraception as required; * HBV DNA within the specified range at screening; * HBsAg was within the specified range at screening. Exclusion Criteria: * Clinically significant abnormalities except chronic HBV infection; * Any clinically significant liver diseases; * Participants with severe infection requiring systemic anti-infection treatment 1 month before enrollment; * Active hepatitis C, HIV antibody positive, treponema pallidum antibody positive; * Hepatobiliary neoplasm malignant; * The laboratory examination results are obviously abnormal; * History of vasculitis or signs and symptoms of potential vasculitis; * Anti-neutrophil cytoplasmic antibodies (ANCA) was positive at screening. * History of extrahepatic disease that may be related to HBV immune status; * Administration of immunosuppressants within 3 months prior to screening, except for short-term use (≤2 weeks) or topical/inhaled steroids. Administration of immunomodulators (thymosin) and cytotoxic drugs within 6 months prior to the first study intervention or have a history of vaccination within 1 month prior to screening or planned administration during the study; * History of malignancy within the past 5 years or the discovery of suspected tumors during the screening period; * Any suspicion of drug component allergy, or allergic constitution (various drug and food allergy, and judged by the investigator to be clinically significant) in participants; * Participants who have significant trauma or major surgery within 3 months before screening, or plan to perform surgery during the study; * Blood donation or blood loss more than 400 mL within 12 weeks before screening; Blood transfusion; Blood donation or blood loss not less than 200 mL within 1 month before screening; * Those who are participating in another clinical trial, or have not undergone a protocol-specified washout period prior to this study; * Participants who have received any oligonucleotide or small molecule interfering ribonucleic acid (siRNA) drugs; * Any other circumstances or conditions for which the investigator considers that the participants are inappropriate to participate in the study.