The study aim to evaluate the efficacy of cord blood eye drops in the healing of the damaged corneal epithelium.
Patients undergoing treatment with EGFR inhibitor for lung cancer might develop corneal damage. The study aims to evaluate the healing of corneal epithelium by administering cord blood eye drops for one month.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Enrollment
10
administration cord blood based eye drops customized to deliver epitelio tropic factors, incluiding EGF in EGFR blocked cells
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy
RECRUITINGCorneal damage measured with National Eye Institute (NEI) score
Evaluation of the effect of cord blood eye drops administration on the variation of corneal damage in patients with severe keratopathy
Time frame: one week before the start of treatment and thirty days after the end of treatment.
Change in discomfort
Symptomatology assessment with OSDI questionnaire. Quality of life analysis with Health-related SF-12 questionnaire, and SEI-QoL subjects' quality of life scale.
Time frame: one week before the start of treatment and thirty days after the end of treatment.
Change in quality of life
Change in QOL measured by SF-12 questionnaire
Time frame: one week before the start of treatment and thirty days after the end of treatment.
Change in quality of life
Change in QOL measured by SEI-QoL questionnaire
Time frame: one week before the start of treatment and thirty days after the end of treatment.
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