A Phase 2 Study of MZE829 in Adults With APOL1 Kidney Disease

Phase 2RecruitingNCT06830629

Maze Therapeutics56 enrolled

Overview

This is purpose of this study is to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with APOL1 Kidney Disease

An open-label Phase 2 study is designed to evaluate the safety, tolerability, and effect on Albuminuria of MZE829 in Adults with Proteinuric Chronic Kidney Disease and the APOL1 High Risk Genotype.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Proteinuric Kidney Disease

Interventions

MZE829DRUG

Capsules for oral administration

Eligibility

Sex: ALLMin age: 18 YearsMax age: 68 Years

Medical Language ↔ Plain English

Key Inclusion Criteria: * APOL1 high risk genotype of G1/G1, G2/G2, or G1/G2 * Chronic kidney disease with persistent albuminuria Key Exclusion Criteria: * Organ or bone marrow transplantation * History of cancer within past 2 years, excepted for treated non-melanoma skin cancer, stage 0 cervical cancer, or stage 1 prostate cancer * Conditions that may alter drug absorption, e.g., history of bariatric surgery * Type I diabetes * Pregnant or currently nursing Other inclusion/exclusion criteria defined in protocol apply.

Locations (74)

Outcomes

Primary Outcomes

Safety and tolerability as assessed by incidence of adverse events (AEs)

Time frame: Day 1 to Week 12

Secondary Outcomes

Percent participants with ≥30% reduction from baseline in UACR at Week 12

Time frame: Day 1 to Week 12

Geometric mean plasma drug concentrations

Time frame: Day 1 to Week 12

Central Contacts

Maze Therapeutics

CONTACT

650-850-5075 APOL1info@mazetx.com

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.

Research Site

Decatur, Alabama, United States

RECRUITING

Research Site

Huntsville, Alabama, United States

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Research Site

Montgomery, Alabama, United States

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Research Site

Granada Hills, California, United States

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Research Site

Bloomfield, Connecticut, United States

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Research Site

Atlantis, Florida, United States

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Research Site

Brandon, Florida, United States

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Research Site

Brooksville, Florida, United States

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Research Site

Hollywood, Florida, United States

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Research Site

Melbourne, Florida, United States

RECRUITING

...and 64 more locations