This non-interventional observational study evaluates the real-world effectiveness and safety profile of ribociclib in combination with an aromatase inhibitor for adjuvant treatment in patients with HR+/HER2- early breast cancer at high risk of recurrence, as well as patient compliance and quality of life.
This non-interventional study aims to provide information on real-world effectiveness, safety and tolerability, management of adverse events, QoL and patient compliance of patients with HR+/HER2- early breast cancer at high risk of recurrence treated with ribociclib in combination with an aromatase inhibitor (AI) ± luteinizing hormone-releasing hormone (LHRH) with curative intent according to the current effective local summary of product characteristics. In order to put the results of patients treated with ribociclib into perspective, socio-economic data, data on QoL and patient compliance will also be collected from patients treated with abemaciclib + endocrine therapy (ET) ± LHRH as described in the current effective local summary of product characteristics. To understand reasons for treatment decision, and to analyze the clinical adoption of ribociclib + AI ± LHRH after EU approval over time, baseline data will be collected from cohorts of ribociclib + AI ± LHRH, abemaciclib + ET ± LHRH, and additionally from patients treated with ET monotherapy ± LHRH and analyzed cross-sectionally. The study is planned to be rolled out into a broad set of German and Austrian breast centers and gynecological practices to describe clinical routine in a representative subset of the local healthcare eco-system. It will gather insights into the potential benefits and risks associated with ribociclib + AI ± LHRH in the adjuvant treatment of HR+/HER2- eBC patients at high risk of recurrence. This knowledge will inform about clinical decision-making and contribute to improved patient outcomes in routine practice.
Study Type
OBSERVATIONAL
Enrollment
3,250
ribociclib in combination with an aromatase inhibitor ± LHRH as described in the current effective summary of product characteristics. This is an observational study. There is no treatment allocation. The decision to initiate treatment will be based solely on clinical judgement.
abemaciclib in combination with an endocrine therapy ± LHRH as described in the current effective summary of product characteristics. This is an observational study. There is no treatment allocation. The decision to initiate treatment will be based solely on clinical judgement.
endocrine monotherapy ± LHRH. This is an observational study. There is no treatment allocation. The decision to initiate treatment will be based solely on clinical judgement.
Novartis Investigative Site
Innsbruck, Tyrol, Austria
RECRUITINGNovartis Investigative Site
Linz, Upper Austria, Austria
RECRUITINGNovartis Investigative Site
Graz, Austria
RECRUITINGNovartis Investigative Site
Klagenfurt, Austria
Invasive disease-free survival (iDFS) for adjuvant therapy with ribociclib + AI ± LHRH in participants with HR+/HER2- eBC at high risk of recurrence
iDFS using STEEP (Standardized Definitions for Efficacy Endpoints in Adjuvant Breast Cancer Trials) criteria, as assessed by the investigator. iDFS is defined as the time from study start to the date of the first event of invasive ipsilateral breast tumor recurrence, local/regional invasive recurrence, distant recurrence, death (any cause), contralateral invasive BC, or second primary non-breast invasive cancer (excluding basal and squamous cell carcinomas of the skin).
Time frame: 36 months
Number of participants per Baseline parameters
Description of available baseline characteristics (e.g. medical history, gender, menopausal status, disease characteristics, laboratory values, socio-economic status, genetic profile, etc.) by treatment cohorts
Time frame: baseline
Reasons for treatment decision by treating physician
Reason for treatment decision documented by the treating physician
Time frame: baseline
Patients' individual perception of risk of recurrence and treatment decision
Patients' individual perception of risk of recurrence and treatment decision assessed by questionnaire at baseline. The questionnaire is provided in two versions, with one version containing 6 items (applicable for the ET mono cohort), and the other version containing 11 items (applicable for ribociclib and abemaciclib cohorts). Responses are primarily given by selecting from predefined options, with some questions allowing multiple answers or prioritization. The scales and response options are designed to reflect individual preferences, concerns, and decision-making processes of patients. Higher scores on the importance scale indicate a stronger motivation to reduce recurrence risk
Time frame: baseline
Invasive disease-free survival (iDFS) (ribociclib cohort)
iDFS using STEEP criteria. iDFS is defined as the time from study start to the date of the first event of invasive ipsilateral breast tumor recurrence, local/regional invasive recurrence, distant recurrence, death (any cause), contralateral invasive BC, or second primary non-breast invasive cancer (excluding basal and squamous cell carcinomas of the skin).
Time frame: 12 and 24 months
Invasive breast cancer-free survival (iBCFS) (ribociclib cohort)
iBCFS using STEEP criteria. iBCFS is defined as the time from study start to the date of the first event of invasive ipsilateral breast tumor recurrence, local/regional invasive recurrence, distant recurrence, death (any cause), or contralateral invasive BC.
Time frame: 12, 24 and 36 months
Recurrence-free survival (RFS) (ribociclib cohort)
RFS using STEEP criteria. RFS is defined as the time from study start to the date of the first event of invasive ipsilateral breast tumor recurrence, local/regional invasive recurrence, distant recurrence, or death (any cause).
Time frame: 12, 24 and 36 months
Distant disease-free survival (DDFS) (ribociclib cohort)
DDFS using STEEP criteria. DDFS is defined as the time from study start to the date of the first event of distant recurrence, death (any cause), or second primary non-breast invasive cancer (excluding basal and squamous cell carcinomas of the skin).
Time frame: 12, 24 and 36 months
Incidence and severity of adverse events (ribociclib cohort)
Incidence and severity of adverse events
Time frame: up to 36 months
Dose modification rates (ribociclib cohort)
Proportion of patients with dose modification and underlying cause
Time frame: up to 36 months
Treatment interruption rates (ribociclib cohort)
Proportion of patients with treatment interruption and underlying cause
Time frame: up to 36 months
Discontinuation rates (ribociclib cohort)
Proportion of patients who discontinued treatment and underlying cause
Time frame: up to 36 months
Time to discontinuation (TTD) (ribociclib cohort)
Time from treatment start to permanent treatment discontinuation
Time frame: up to 36 months
Quality of life by EORTC QLQ-C30 (ribociclib and abemaciclib cohorts)
Changes from baseline as assessed by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-C30. The EORTC QLQ-C30 is a participant completed 30 item questionnaire that is composed of both multi-item scales and single-item measures. These include five functional scales, three symptom scales, six single items and a GHS/QoL scale. All of the scales and single-item measures range in score from 0 to 100. A high scale score represents a higher response level.
Time frame: up to 39 months
Quality of life by EORTC QLQ-BR42 (ribociclib and abemaciclib cohorts)
Changes from baseline as assessed by European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ)-BR42. The Breast Cancer Module EORTC QLQ-BR42 is a 42 item instrument designed to measure quality of life in breast cancer participants. It includes three functional scales, six symptom scales and three single items. All the scales and single item measures range in score from 0 to 100. A high scale score represents a higher response level.
Time frame: up to 39 months
Quality of life by HADS D (ribociclib and abemaciclib cohorts)
Changes from baseline as assessed by the Hospital Anxiety and Depression Scale (HADS D). The HADS is a participant completed fourteen item scale. Seven of the items relate to anxiety and seven relate to depression. The anxiety and depression subscales each range from 0 to 21, with higher scores indicating higher anxiety/depression complains.
Time frame: up to 39 months
Participant compliance as assessed by the Medication Adherence Report Scale (MARS-D) (ribociclib and abemaciclib cohorts)
Medication Adherence Report Scale (MARS-D) questionnaire is a 5-item questionnaire measuring non-adherence. Each item is ranging from "never" (5 points) to "always" (1 point), with a total score 5-25 where higher scores indicate better compliance.
Time frame: up to 36 months
Participant compliance as assessed by a physician adherence rating (ribociclib cohort)
Participant compliance as assessed by a physician adherence rated as very good, good, moderate, or poor.
Time frame: up to 36 months
Participant compliance as assessed by neutrophil count (ribociclib cohort)
Participant compliance as assessed by neutrophil count.
Time frame: up to 36 months
Impact of type and change of treatment facility and health care professionals involved in treatment management on participant compliance assessed by MARS-D (ribociclib cohort)
Medication Adherence Report Scale (MARS-D) questionnaire is a 5-item questionnaire measuring non-adherence. Each item is ranging from "never" (5 points) to "always" (1 point), with a total score 5-25 where higher scores indicate better compliance.
Time frame: up to 36 months
Impact of digital health solutions applied in clinical routine on participant compliance assessed by MARS-D (ribociclib cohort)
Medication Adherence Report Scale (MARS-D) questionnaire is a 5-item questionnaire measuring non-adherence. Each item is ranging from "never" (5 points) to "always" (1 point), with a total score 5-25 where higher scores indicate better compliance.
Time frame: up to 36 months
Socio-economic status of participants measured by WPAI-GH (ribociclib and abemaciclib cohorts)
The Work Productivity and Activity Impairment - General Health questionnaire (WPAI-GH) is a participant completed 6 item questionnaire which addresses absenteeism, presenteeism, overall work productivity loss, and activity impairment for the 7 days prior to the assessment. WPAI outcomes are presented as impairment percentages (range goes from 0 to 100 with a higher percentage indicating greater impairment and less productivity).
Time frame: up to 39 months
Number of participants per reason for treatment discontinuation (ribociclib and abemaciclib cohorts)
Reported reasons for treatment discontinuation
Time frame: up to 39 months
Type of subsequent anti-neoplastic therapies (ribociclib and abemaciclib cohorts)
Type of subsequent anti-neoplastic therapies will be recorded
Time frame: up to 39 months
Time to subsequent anti-neoplastic therapy (ribociclib and abemaciclib cohorts)
Time from study start to first subsequent anti-neoplastic therapy
Time frame: up to 39 months
Impact of an active participation of the participant in the treatment decision on subsequent participant compliance measured by MARS-D (ribociclib cohort)
Participant compliance assessed by MARS-D and active participation of the participant in the treatment decision assessed by the questionnaire "Fragebogen zur partizipativen Entscheidungsfindung aus Participantensicht" (PEF-FB-9) and "Fragebogen zur partizipativen Entscheidungsfindung aus Sicht des Arztes"(PEF-FB-Doc) at baseline. The MARS-D is a 5-item questionnaire measuring non-adherence with a total score of 5-25 where higher scores indicate better compliance. The PEF-FB-9 is a participant completed 9 item questionnaire for participant participation in decision-making. The 9 items are rated on a 6-point scale with endpoints ranging from "does not apply at all" to "applies completely", summed up and transformed into a scale from 0 to 100. The higher the total score, the higher the perceived degree of participation. The PEF-FB-Doc is the physician version of the PEF-FB-9. The correlation between participation on treatment decisions and participant compliance will be presented.
Time frame: up to 36 months
Impact of participants' fear of cancer recurrence on participant compliance measured by MARS-D (ribociclib cohort)
Participant compliance assessed by MARS-D and participants' fear of cancer recurrence assessed by the Fear of Cancer Recurrence (FCR)-1 questionnaire. The MARS-D questionnaire is a 5-item questionnaire measuring non-adherence. Each item is ranging from "never" (5 points) to "always" (1 point), with a total score 5-25 where higher scores indicate better compliance. The FCR-1 is a participant completed 1 item questionnaire asking the participant to describe their subjective level of fear of cancer recurrence at the given time on a scale from 0 to 100 with 100 being the greatest fear. The correlation between participants' fear of recurrence and participant compliance will be presented.
Time frame: up to 36 months
Participants' expectations regarding therapy, side effects and management (ribociclib and abemaciclib cohorts)
Treatment expectation assessed by a questionnaire containing 5 questions with each 5-7 ordinal answer categories with the same directionality on participants' expectations regarding therapy, side effects and management
Time frame: baseline
Participants' treatment satisfaction (ribociclib and abemaciclib cohorts)
Treatment satisfaction assessed by a questionnaire containing 5 questions with each 5-7 ordinal answer categories with the same directionality on treatment satisfaction
Time frame: up to 24 months
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Novartis Investigative Site
Leoben, Austria
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Schwaz, Austria
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Steyr, Austria
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Vienna, Austria
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Vienna, Austria
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Vienna, Austria
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