ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment. Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
30
Mixture of amino acids (67 g / 500 ml) given intravenously
Karolinska University Hospital
Stockholm, Sweden
RECRUITINGBalance of amino acids
Total balance of amino acid losses and supplementation given
Time frame: After 3 days of dialysis
Amino acid concentration in plasma
Concentration of various amino acids in plasma without and with supplementation
Time frame: After 3 days of dialysis
Concentration of vitamins and trace elements
Analysis of various trace elements and vitamins
Time frame: After 3 days of dialysis
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