Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure

University Hospital Marburg1,000 enrolled

Overview

The present study is a prospective study on the development of seizure frequency, medication adherence, quality of life and cognitive performance after a first epileptic seizure using the new diagnostic criteria for epilepsy of the International League Against Epilepsy of 2014 at the time of diagnosis.

The new diagnostic criteria for epilepsy, which have been in place since 2014, suggest that due to the improved possibilities for early diagnosis and treatment - particularly as a result of improved imaging diagnostics - changes in the incidence rates and severity of the course of epilepsies with different etiologies can be expected. The group of epilepsies with unclear etiology should now be smaller than in previous studies. The MRI- and EEG-positive patients can now be identified as having structural epilepsy based on the type of lesion, which was not possible in previous studies without differentiated imaging. The fact that these patients can now be treated before a patients can now be treated before a second seizure, the risk of recurrence and the health economic costs should also be reduced and have a positive effect on maintaining cognitive performance and quality of life after a first epileptic seizure. The aim of the study is to record the consequences of the new epilepsy diagnostic criteria in terms of outcome and treatment. In addition, the investigators will use a questionnaire battery and neuropsychological testing to record the potential neuropsychological deficits, financial and socio-medical consequences of a first seizure or early-stage epilepsy.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Seizure, Epileptic Neuropsychology Outcome

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Completion of the 18th year of life * first epileptic seizure * Ability to understand the patient information and to give written consent * Written consent for voluntary participation in the study Exclusion Criteria: * Chronic drug or alcohol abuse in the last two years

Locations (1)

c/o Klinik für Neurologie

Marburg, Hesse, Germany

RECRUITING

Outcomes

Primary Outcomes

Rate of seizure recurrency

Seizure recurrency is recorded 6 months, 1 year, 3 years, 5 years and 10 years after the first seizure

Time frame: 10 Years

Secondary Outcomes

employment

Currently working as employee or independent, retirement or long-time sick-leave at the first attack, after 6 months, 1, 3, 5 and 10 years.

Time frame: 10 years

Salary

Gross salary in Euro at the first attack, after 6 months, 1, 3, 5 and 10 years.

Time frame: 10 years

Driving restriction

Fitness to drive (yes/no) is assessed after the first attack, after 6 months, 1, 3, 5 and 10 years.

Time frame: 10 Years

Verbale Lern- und Merkfähigkeitstest

Verbale Lern- und Merkfähigkeitstest - VLMT (Helmstaedter, Lendt, \& Lux, 2001) at baseline and then after 1 years, 5 years and 10 years after the first seizure: 0 to 135 points, O worst, 135 best possible result.

Time frame: 10 years

Regensburger Wortflüssigkeits-Test

Regensburger Wortflüssigkeits-Test - RWT (Aschenbrenner, Tucha, \& Lange, 2000) at baseline and then after 1 years, 5 years and 10 years after the first seizure: Number of words starting with one asked letter, that can be said in 2 minutes (typically between 0 and 50)

Time frame: 10 Years

Copy and recall of the Rey-Osterrieth Figure

Copy and recall of the Rey-Osterrieth Figure (Berry, Allen, \& Schmitt, 1991) at baseline and then after 1 years, 5 years and 10 years after the first seizure: 0 to 36 points. 0 worst possible result, 36 best possible result.

Data from ClinicalTrials.gov

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