The goal of this study is to evaluate the effects of LC-Plasma on the innate and acquired immune systems, including the activation of pDCs, which play a role in virus elimination, as well as to assess its efficacy in reducing clinical symptoms of upper respiratory infectious diseases in healthy adults. Researchers will compare LC-Plasma to placebo, participants will take a tablet containing LC-Plasma or placebo daily for 4 weeks.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
241
Griffith University
Southport, Queensland, Australia
The degree of activation of plasmacytoid dendritic cells (pDCs)
The degree of activation of plasmacytoid dendritic cells (pDCs) is measured using the indicators CD304+/CD123+, CD86+, or HLA-DR+
Time frame: Week 0 to week 4
Activation of Cytotoxic T Lymphocytes (CTLs)
The evaluation of CTLs responsible for virus elimination will be determined using the indicator (CD8+/CD3+/CD4-/IFN-γ+).
Time frame: Week 0 to week 4
Anti-viral Activity of PBMCs
The anti-viral activity gene expression and IFN-α \& β production capability of PBMCs, both unstimulated and mildly stimulated with CpG, will be measured.
Time frame: Week 0 to week 4
WURSS-24 Symptom Score
Symptoms will be measured using the Wisconsin Upper Respiratory Symptom Survey (WURSS-24)
Time frame: Week 0 to week 4
Rapid antigen test (RAT)
Rapid antigen test (RAT) for Flu A/B, RSV \& SARS-CoV-2. Will be conducted by participants once per week, with additional tests if symptoms are present.
Time frame: Week 0 to week 4
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