Follicular Volume at the Time of Final Oocyte Maturation in Poor Responders, and Its Correlation With Oocyte Maturity

ART Fertility Clinics LLC100 enrolled

Overview

Women with a severely diminished ovarian reserve and monofollicular growth are at a higher risk of premature ovulation as well as poor quality oocytes. Our group showed previously that women with severely diminished ovarian reserve benefit from receiving the final oocyte maturation at smaller follicle sizes in terms of reducing the risk of premature ovulation and finding mature oocytes even out of small size follicles. Adding the measurement of the follicular volume at the time of final oocyte maturation might provide more information on the proper timing of trigger administration compared to the follicular size alone, hormonal profile as well as previous stimulation attempts. Setting a cutoff value of follicular volume for trigger might help to avoid premature ovulation and possibly increase the chances of ending up with a euploid embryo.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

OVARIAN STIMULATION

Interventions

transvaginal UltrasoundOTHER

The only additional measure will be the measurement of the follicle volumes on the day of trigger and before oocyte pick up procedure. This will be performed at the same time as the pre Oocyte pick up ultrasound prior to the patient admission to the recovery room for preparation. The ultrasound that will be used already has a pre build program that calculates the follicular volume automatically and hence not extending the ultrasound time.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 48 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Reproductive age group: 18 -48 * undergoing ovarian stimulation for oocyte vetrification * undergoing IVF/ ICSI with PGT-A / PGT-M / PGT- Sr * less than or equal to 3 AFC on initiation of stimulation * follicular phase stimulation Exclusion Criteria: * surgically retrieved sperm

Outcomes

Primary Outcomes

the investigators will see the corellation between the follicular volume at the time of trigger with the oocyte maturity in patients with less than four follicles of a follicle size of at least 11 mm .

The objective of this study is to evaluate the relationship between follicular volume at the time of trigger and oocyte maturity in patients undergoing assisted reproductive techniques, specifically those with fewer than four follicles of at least 11 mm in size. This study aims to determine whether follicular volume just before trigger is a significant predictor of oocyte maturation. By focusing on this specific patient group, the study seeks to provide insights that could inform treatment strategies and improve outcomes in assisted reproductive technology.

Time frame: 1 year