Effects of the Adjunctive Use of Hyaluronic Acid-based Gel in the Surgical Periodontal Treatment of Periodontitis

Ordu University18 enrolled

Overview

This study aimed to assess the effect of Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent in surgical periodontal treatment on clinical parameters and cytokine levels (IL-6, IL-8, IL-10, IL-17A, TOS, and TAS) in gingival crevicular fluid (GCF) among periodontitis patients.

The aim of this study is to evaluate the effects of adjunctive Hyaluronic Acid-Based Gel (HA) application in the surgical treatment of patients with moderate to severe stage III periodontitis (Grade B or C) on clinical parameters, as well as on IL-6, IL-8, IL-10, IL-17, TAS, and TOS levels in gingival crevicular fluid (GCF) to determine its anti-inflammatory and antioxidant efficacy. This split-mouth study included 18 patients (mean age 43.44±8.12 years) diagnosed with Stage III Grade B or C periodontitis. Quadrants were randomly assigned to two groups: Group 1 (control: open flap debridement \[OFD\], n=18) and Group 2 (test: OFD + 0.8% HA gel, n=18). Baseline (T0) assessments included plaque index (PI), gingival index (GI), bleeding on probing index (BPI), probing pocket depth (PPD), clinical attachment level (CAL), and GCF collection. Following non-surgical treatment, patients underwent OFD; HA gel was applied to defect sites in the test group and saline in the control. Clinical parameters and GCF sampling were repeated pre-surgery (TS-1), and at 1 month (TS-2) and 6 months (TS-3) post-surgery.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Periodontitis (Stage 3)

Interventions

open flap debridement and Hyaluronic Acid-Based Gel applicationDRUG

Hyaluronic Acid-based gel as an adjunctive chemotherapeutic agent

open flap debridementPROCEDURE

periodontal surgery technique

Eligibility

Sex: ALLMin age: 25 YearsMax age: 55 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Stage III Grade B or C periodotitis * over 18 years old * signed the informed consent Exclusion Criteria: * pregnancy, or lactation, * systemic problems that would contraindicate for periodontal surgery, * prosthetic restorations in the test or control teeth, * taking medications that affect wound healing (corticosteroids, anticancer agents, etc), * using nonsteroidal anti-inflammatory drugs, using any antibiotics and anti-inflammatory drugs in the last 6 months, * alcohol abuse and smoking use

Locations (1)

Ordu University

Ordu, Altınordu, Turkey (Türkiye)

Outcomes

Primary Outcomes

Plaque Index

to assess plaque accumulation

Time frame: Baseline

Plaque Index

to assess plaque accumulation

Time frame: Pre-surgery

Plaque Index

to assess plaque accumulation

Time frame: post-surgery 1 month

Plaque Index

to assess plaque accumulation

Time frame: post-surgery 6 months

Gingival Index

for evaluating gingival inflammation

Time frame: Baseline

Gingival Index

for evaluating gingival inflammation

Time frame: Pre-surgery

Gingival Index

for evaluating gingival inflammation

Time frame: post-surgery 1 month

Gingival Index

for evaluating gingival inflammation

Time frame: post-surgery 6 months

Probing pocket depth

for measuring disease severity

Time frame: Baseline

Probing pocket depth

for measuring disease severity

Time frame: pre-surgery

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.