Blood Tuberculosis DNA Levels to Monitor Tuberculosis Treatment

Inclusion Criteria: Participants with a new diagnosis of tuberculosis * Aged ≥ 18 years old * Newly microbiologically confirmed (culture or nucleic acid amplification test) diagnosis of Mycobacterium tuberculosis (Mtb.) infection (of any site) * Has not yet commenced antituberculosis therapy * Able to understand study procedures and requirements and is able to give informed consent For healthy volunteers: * Aged ≥ 18 years old * Healthy as judged by a responsible physician * Able to understand study procedures and requirements and is able to give informed consent Exclusion Criteria: Participants with a new diagnosis of tuberculosis * Exposure to antituberculosis treatment in the last 8 weeks (or Mycobacterium tuberculosis (Mtb.) active fluoroquinolone) * Known history of underlying malignancy * Pregnancy * Transfusion dependent anaemia For healthy volunteers: * History of tuberculosis infection or latent tuberculosis infection * Household, or other close contact, of a person living with tuberculosis disease * Chest radiograph (CXR) changes suggestive of pulmonary tuberculosis * Presence of symptoms which would otherwise indicate screening for tuberculosis (cough \> 2 weeks duration, fever, weight loss, night sweats) * Other major medical comorbidity * Pregnancy * Known malignancy