The Effect of Mannitol Volume With Changes in Osmolarity in Traumatic Brain Injury

Universitas Diponegoro64 enrolled

Overview

This observational study is designed to research the effect of mannitol volume administration with changes in osmolarity in patients with traumatic brain injury to guide the safe use of mannitol in these patients.

This prospective observational cohort study included 64 non-operative TBI patients admitted to Dr. Kariadi Central General Hospital, Semarang, Indonesia, between November 2023 and January 2024. Patients received one of three routine clinical regimens: 3×0.25 g/kg, 2×0.5 g/kg, or 3×0.5 g/kg body weight. Mannitol was administered intravenously over 15-20 minutes per dose. Plasma osmolarity was measured at baseline and at 6 and 24 hours following initial administration.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Anesthesia Traumatic Brain Injury

Interventions

MannitolDRUG

mannitol administration across all three dosages given as an IV drip for 15-20 minutes

Eligibility

Sex: ALLMin age: 18 YearsMax age: 40 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged 18-40 years * Glasgow Coma Scale (GCS) score indicating mild (14-13) or moderate (12-10) Exclusion Criteria: * Renal impairment * Multiple trauma with bleeding shock * Diabetes mellitus

Locations (1)

Dr. Kariadi Central General Hospital

Semarang, Central Java, Indonesia

Outcomes

Primary Outcomes

Osmolarity

Blood osmolarity (mOsm/L)

Time frame: At baseline (before administration) and subsequently at 6 hours and 24 hours post-administration

Data from ClinicalTrials.gov

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