The goal of this clinical trial is to learn if Dextrose 10% or superhydration works to prevent postoperative nausea and vomiting in patients undergoing laparoscopic cholecystectomy. . The main questions it aims to answer are: Does Dextrose 10% or superhydration lower the number of times participants gets an episode of nausea and vomititng after laparoscopic cholecystectomy surgery? Researchers will compare Dextrose 10% versus superhydration to a placebo (a look-alike substance that contains no drug) to see if glucose 10% or superhydation can work to prevent postoperative nausea and vomiting. Participants will: Take Dextrose 10% or superhydration or a placebo in the operation monitored for 4 hours after surgery to check on their nausea and vomiting state
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
204
ringer lactate 20 ml/kg over the first 90 to 120 minutes after induction intraoperatively
Dextrose 10% 250 ml over 60 minutes
Faculty of Medicine Ain Shams University
Cairo, Abbassia, Egypt
To compare the incidence of Post operative nausea and vomiting in the study treatment groups
Time frame: Postoperative 4 hours stay in PACU
Frequency of vomiting episodes
Time frame: Postoperative 4 hours stay in PACU
Measurement of PONV severity scores
Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn't need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour
Time frame: Postoperative 4 hours stay in PACU
Time from extubation till discharge from PACU
Time frame: From the moment of extubation till the moment of discharge from PACU with patient being completely vitally stable and nausea and vomiting free , assessed to be from 4 to 8 hours
total antiemetic medication consumption
Severity of PONV was assessed using a 4-point Verbal Descriptive Scale (VDS) which consists of: Score 0= no PONV: no complaint of nausea or vomiting; Score 1= mild PONV: patient complains from nausea but doesn't need antiemetic treatment. Score 2= moderate PONV: patient complains from nausea and need antiemetic treatment; Score 3= severe PONV: patient complains from nausea with episode of vomiting requiring antiemetic treatment. PONV scores were obtained every half hour, Rescue antiemetic granisetron 1 mg IV was given when VDS scores were 2 or more. Medications were given only after excluding other causes of PONV such as hypovolemia, hypotension, hypoxia. The total number of doses of antiemetics used were obtained every half hour from the time of entry to the PACU for 4 hours
Time frame: Postoperative period 4 hours stay in PACU. ( if the patient needed to stay for longer duration in the PACU for any medical reason then any antiemetic used in this period will be recorded as well )
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