Application of tear ferning test for clinical dry eye diagnosis and menopause
Analyzing the difference in tear ferning structure between women pre and post-menopause with and without hormone replacement therapy (HRT). Tear and blood samples were collected for a menopause-related Enzyme-linked immunosorbent assay. Tear volume, tear osmolarity, intraocular pressure, and tear break-up time were also measured for comparison.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
90
Compare tear ferning structure between pre-menopause and post-menopause women.
Jen-Ai Hospital
Taichung, Taiwan, Taiwan
RECRUITINGSchirmer's test
To assess tear secretion volume
Time frame: 5 minutes
Tear film breakup time
To assess tear quality
Time frame: 20 seconds
Ocular surface status
To assess ocular surface health status with lissamine green stain, health or corneal abrasion.
Time frame: 3 minutes
Tear ferning
crystal structure formed from tear drops on a slide be scored.
Time frame: 30 minutes
Menopause related hormone Enzyme-linked immunosorbent assay (ELISA)
To assess FSH/LH/E2/Progesterone/Mc5AC/Lactoferrin concentration between pre- and post-manopause women.
Time frame: 3 hours
Ocular surface disease index
A questionnaire to assess the health status on ocular surface A final score is calculated which ranges from 0 to 100 with scores 0 to 12 representing normal, 13 to 22 representing mild dry eye disease, 23 to 32 representing moderate dry eye disease, and greater than 33 representing severe dry eye disease.
Time frame: 20 minutes
Intraocular pressure
To determine the effects of intervention on intraocular pressure
Time frame: 2 minutes
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