Childbirth is an intense physical and psychological experience. Epidural analgesia (EP) remains the gold standard in labor pain management. However, continuous refinements are aimed at enhancing analgesic quality and mitigating adverse effects. In recent years, the dural puncture epidural (DPE) technique has gained popularity. In this technique, the dura is intentionally punctured with a spinal needle before the epidural catheter is placed, but no intrathecal medication is administered. This historically controlled study evaluates the clinical outcomes of a protocol transition from standard high-dose epidural to low-dose DPE. The primary objective is to compare total analgesic consumption and success rates of labor analgesia between the two techniques. The secondary objectives include the assessment of hemodynamic parameters, motor block characteristics, adverse effects (such as paresthesia and hypotension), and overall maternal satisfaction
The maternal pain experience encompasses psychological and emotional components, highlighting the necessity for patient-centered assessment approaches. While standard epidural and combined spinal-epidural (CSE) techniques are common, they carry risks such as inadequate sacral coverage, motor block, or fetal bradycardia. The dural puncture epidural (DPE) technique aims to combine the advantages of EP and CSE while minimizing their disadvantages. By creating a dural hole, DPE facilitates the translocation of epidural medications into the subarachnoid space, aiming to accelerate the onset of analgesia and improve block quality.This single-center, historically controlled study consists of two consecutive cohorts managed before and after a change in the clinical protocol. Group 1 (retrospective control) received standard concentration epidural analgesia. Group 2 (prospective intervention) received the low-dose DPE technique. The study hypothesizes that the low-dose DPE technique provides non-inferior analgesic efficacy with significantly reduced total bupivacaine consumption and a superior side-effect profile compared to the standard high-dose EP technique. Outcomes evaluated include total bupivacaine consumption, adequate analgesia success (NRS \< 4), maternal hemodynamic changes, incidence of adverse effects including paresthesia, and patient satisfaction
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
100
Administration of conventional epidural analgesia using an 18G Tuohy needle for catheter placement and subsequent administration of a standardized dose of bupivacaine with fentanyl.
Administration of epidural analgesia that incorporates a dural puncture with a 27G spinal needle prior to epidural catheter placement, followed by the same standardized dose of bupivacaine with fentanyl.
Medipol University
Istanbul, Turkey (Türkiye)
Total Analgesic Consumption
Cumulative bupivacaine consumption measured in milligrams.
Time frame: From the initiation of epidural analgesia until delivery.
Adequate Analgesia Achievement
Proportion of participants achieving a target Numeric Rating Scale (NRS) score of less than 4
Time frame: Assessed at 15 minutes post-procedure and during hourly follow-ups until delivery.
Incidence of Adverse Effects
Recording of adverse effects including nausea, vomiting, pruritus, hypotension, and paresthesia
Time frame: Continuously monitored from the initial epidural dose until delivery.
Requirement for Supplemental Analgesia
Total number of supplemental boluses required during labor
Time frame: From the initiation of epidural analgesia until delivery.
Maternal Satisfaction
Documented patient satisfaction levels regarding the childbirth experience
Time frame: Assessed in the early postpartum period.
Post-Dural Puncture Headache
Incidence and severity of post-dural puncture headache in the postpartum period.
Time frame: Up to 1 week postpartum.
Incidence and Severity of Motor Block
Occurrence and degree of motor block, evaluated by the Modified Bromage Scale.
Time frame: Monitored throughout the procedure until delivery.
Maternal Hemodynamic and Fetal Heart Rate Variations
Variation in maternal blood pressure, heart rate, and fetal heart rate changes.
Time frame: Continuously monitored throughout the procedure.
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