Antibiotic Exposure on Gut Microbiota and Motility Establishment in Newborns

N/AActive Not RecruitingNCT06850896

The First Hospital of Jilin University200 enrolled

Overview

This prospective cohort study aims to investigate the impact of early antibiotic exposure on the establishment of gut microbiota and motility in newborns, particularly preterm infants. The study will explore the correlation between antibiotic exposure, gut microbiota colonization, and 5-hydroxytryptamine (5-HT) levels, which are critical for gastrointestinal motility. The findings may provide insights into optimizing antibiotic use and improving gastrointestinal health in neonates.

Study Type

OBSERVATIONAL

Enrollment

200

Conditions

NEC - Necrotizing Enterocolitis

Eligibility

Sex: ALLMin age: 24 WeeksMax age: 36 Weeks

Medical Language ↔ Plain English

Inclusion Criteria: * Newborns admitted within 72 hours of birth * Gestational age 24-36 weeks (preterm) and term infants * Informed consent obtained from parents or guardian Exclusion Criteria: * Congenital gastrointestinal malformations (e.g., intestinal atresia, Hirschsprung's disease) * Severe systemic or organ-specific diseases * Expected mortality due to severe illness

Locations (1)

The first hospital of Jilin university

Changchun, Jilin, China

Outcomes

Primary Outcomes

gut microbiota

Impact of antibiotic exposure on gut microbiota colonization assessed by 16S rRNA sequencing.

Time frame: Enrollment Period: This is the time during which participants will be recruited and enrolled into the study. You have specified that enrollment will occur from November 2024 to November 2027. Intervention Period: Since this is an observational study, the

Data from ClinicalTrials.gov

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