This study will enroll women with PCOS to study the effects of first line therapy, oral contraceptive pills, and then either 12 weeks of resistant starch or 12 weeks of placebo to explore if resistant starch improves cardiometabolic parameters or impacts gut dysbiosis compared to placebo.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
100
participants will take 15 grams per day for 12 weeks
20 micrograms ethinyl estradiol and desogestrel 0.15mg
participants will take 15 grams per day for 12 weeks
University of Pennsylvania
Philadelphia, Pennsylvania, United States
RECRUITINGChange in LDL-C measure
Time frame: Baseline and 12 weeks
Change in fasting glucose measure
Time frame: Baseline and 12 weeks
Change in systolic blood pressure
Time frame: Baseline and 12 weeks
Change in diastolic blood pressure
Time frame: Baseline and 12 weeks
Change in BMI
Time frame: Baseline and 12 weeks
Change in Bifidobacteria abundance measured by quantitative polymerase chain reaction (q-PCR)
Time frame: Baseline and 12 weeks
Change in Single Chain Fatty Acids (SCFA)
Time frame: Baseline and 12 weeks
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