The aim of the present study is to evaluate the protective impact of cardioprotective medications on the chemotherapy- induced cardiotoxicity.
The goal of this interventional study is to evaluate the protective impact of Angiotensin-converting enzyme (ACE) inhibitors versus β-blockers on the cardiotoxicity profile of pediatric patients with acute leukemia. The impact is measured by evaluation of left ventricular ejection fraction (LVEF) by 2D echocardiography at baseline and at the end of Induction phase (42 days).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
30
0.3 mg/kg/dose every 8 hours orally by either a caregiver or caring nurse.
0.05 mg/kg/dose every 12 hours orally by either a caregiver or caring nurse.
Faculty of Pharmacy, Ain Shams University
Cairo, Egypt
RECRUITINGFaculty of Pharmacy, Ain Shams University
Cairo, Egypt
RECRUITINGChange in Left Ventricular Ejection Fraction (LVEF)
he LVEF will be measure by 2D Echocardiography at baseline and at the end of Induction Phase (42 Days)
Time frame: LVEF will be measured at Baseline and at the end of Induction Phase (42 Days)
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