The variable course of Alzheimer's disease (AD) and the paucity of adequate cures urges to implement new strategies for its early detection and clinical intervention. Studying the etiopathogenesis and pathophysiological mechanisms of AD is a necessary prerequisite for the development of new biomarkers and innovative therapies. Contrarily to anatomical structures, cortical connectivity networks are already deteriorated in early AD and could be a reliable marker of early cognitive decline. Our aim is to characterize the neurophysiological parameters in mild AD, in patients with mild cognitive impairment and in matched healthy subjects to identify discriminating criteria. Concurrently, the study of AD onset and progression in a mouse model, will allow evaluating the causal effect of inflammation on disease progression and to develop a new class of biomimetic anti-inflammatory nanoparticles formulated to have the intrinsic ability to induce brain's activated microglia to an M2 phenotype.
Study Type
OBSERVATIONAL
Enrollment
300
IRCCS San Raffaele
Roma, Italy
ACTIVE_NOT_RECRUITINGAzienda Ospedaliero-Universitaria di Sassari
Sassari, Italy
RECRUITINGIdentification of Disease-Associated Phenotypes in MCI and AD
Time frame: through study completion, an average of 1 year
Identification of Disease-Associated Early Interventions in MCI and AD
Time frame: through study completion, an average of 1 year
Predictive Power of EEG-Based Brain Network Analyses for MCI to AD Conversion
EEG power spectral density
Time frame: through study completion, an average of 1 year
Evaluation of Targeting Efficiency of Activated vs Native Leukosomes in Brain Inflammation
Time frame: through study completion, an average of 1 year
Evaluation Trafficking Kinetics of Activated vs Native Leukosomes in Brain Inflammation
Time frame: through study completion, an average of 1 year
Assessment of Activated Leukosomes in Inducing Anti-Inflammatory Polarization of Macrophages
Time frame: through study completion, an average of 1 year
Assessment of Activated Leukosomes in Glial Cells
Time frame: through study completion, an average of 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.