Perioperative Analgesia With Erector Spinae Plane Block in Liver Transplant Recipients

Bogomolets National Medical University50 enrolled

Overview

The goal of this clinical trial is to learn if ESP block is safe and effective for perioperative analgesia in patients undergoing liver transplant. The main question it aims to answer are Is ESP block safe and has a minimum side effects, like hematoma? Is it effective for perioperative analgesia? Researchers will compare the results to a group of patients who underwent liver transplants without any regional anaesthesia techniques. Participants will receive bilateral thoracic ESP block on the day of the transplantation with a subsequent bilateral catheterization.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Liver Transplant Erector Spina Plan Block

Interventions

Bilateral thoracic ESP block on the day of the transplantation with a subsequent catheterization will be suggested for the patients. In case of their written consent for the participation in the study this procedure will be performed on the day of the operation. 0.2% ropivacaine is going to be used throughout all the perioperative period.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * impaired liver function - cirrhosis or chronic liver disease with the development of hypocoagulation (APTT \> 35 sec, INR \> 1.5), thrombocytopenia, patients requiring major abdominal surgery, age \> 18 years, written consent to participate in the study was obtained Exclusion Criteria: * Platelet count \<50x109, failed ESP catheterization unilateral or bilateral, failed epidural anesthesia attempt, history of allergy or hypersensitivity to local anesthetics, hepatopulmonary syndrome, patients on mechanical ventilation before surgery, patients on CRRT before surgery, refusal to participate in the study

Outcomes

Primary Outcomes

Pain reduction postoperative

Pain assessment with scores

Time frame: from enrollment to the 2nd postoperative day

Opioid reduction intraoperatively

The amount of intraoperative fentanyl

Time frame: from enrollment to the end of the operation

Need for opioids postoperatively