A Study on the Safety, Tolerability and Pharmacokinetics of WS-0101 Tablets in Chinese Healthy Subjects

Inclusion Criteria: * Subjects must meet the following criteria to be included in this study: 1. Voluntarily participate in the study and provide a signed and dated informed consent form (ICF). 2. Be a male or female adult between 18 and 55 years of age (inclusive). 3. Male subjects must weigh at least 50 kg, and female subjects must weigh at least 45 kg, with a body mass index (BMI) between 18.5 and 28 kg/m² (inclusive). 4. For female subjects: 1. No reproductive potential, including at least 6 weeks post-surgical sterilization (documented tubal ligation, hysterectomy, or bilateral oophorectomy) or ≥12 months of postmenopausal status (with follicle-stimulating hormone (FSH) levels ≥40 IU/L). 2. For women of childbearing potential, they must be non-pregnant, non-lactating, and must agree to use non-drug contraceptive methods for 30 days before administration, throughout the study, and for 3 months after dosing. Their human chorionic gonadotropin (hCG) test must be negative at screening and on Day -1, and they must not donate eggs during this period. 5. For male subjects with female partners of childbearing potential, they must agree to use non-drug contraceptive methods for 14 days before administration, throughout the study, and for 3 months after dosing. Male subjects must not donate sperm during this period. 6. Willingness to comply with the study protocol, including visits, study treatment, laboratory tests, and other study-related procedures and requirements. Exclusion Criteria: * Subjects meeting any of the following criteria will be excluded from the study: 1. Known allergy to the study drug or its excipients, or allergy to blue light sources, or a history of severe allergies (including any food or drug allergies). 2. A history of photosensitivity disorders, such as polymorphic light eruption, solar urticaria, chronic actinic dermatitis, porphyria, or any suspected photosensitivity based on the investigator's judgment. 3. A history of recurrent skin infections, psychiatric disorders, a family history of psychiatric disorders, or chronic or serious conditions involving the central nervous system, cardiovascular system, liver, kidneys, lungs, digestive tract, metabolism, blood, or skeletal systems that could affect study participation or pose unacceptable risks. 4. Sensitivity, infection, inflammation, redness, rash, sunburn, blistering, injury, pigmentation changes, or the presence of tattoos, birthmarks, or scars at the application site. 5. Exposure of the upper arms to sunlight or artificial tanning within 48 hours prior to dosing. 6. Keloid formation or scarring tendencies. 7. Clinically significant abnormalities in vital signs, physical examination, or laboratory tests. 8. Clinically significant abnormalities on a 12-lead electrocardiogram (ECG). 9. A creatinine clearance rate (Ccr) of less than 90 mL/min, calculated using the Cockcroft-Gault formula: Ccr=((140-Age)\*Weight(Kg)\*(0.85 for women))/(72\*Serum creatinine (mg/dL)) Alternatively: Ccr=((140-Age)\*Weight(Kg)\*(0.85 for women))/(0.81\*Serum creatinine (μmol/dL)) 10. Positive for human immunodeficiency virus antibodies (HIV-Ab), hepatitis B surface antigen (HBsAg), hepatitis C virus antibodies (HCV-Ab), or syphilis antibodies (TP-Ab). 11. Use of any prescription, over-the-counter medication, herbal medicine, or dietary supplements within 14 days before dosing, or use of photosensitizing or phototoxic drugs (e.g., quinolones, glibenclamide, sulfonamides, tetracyclines, chloramphenicol, phenothiazines) within 3 months before dosing. 12. Known or suspected history of substance abuse (e.g., morphine, methamphetamine, ketamine, MDMA, THC, cocaine), or a positive drug screen. 13. Excessive alcohol consumption (more than 21 units per week; one unit equals 14 g alcohol, e.g., 360 mL of 5% beer, 45 mL of 40% spirits, or 120 mL of 12% wine) within 1 year prior to screening, or a positive alcohol breath test. 14. Smoking more than 5 cigarettes per day within 3 months prior to screening, or an inability to comply with the study's smoking restrictions. 15. Daily consumption of more than 6 servings of caffeine (e.g., coffee, tea, cola, energy drinks) within 3 months prior to screening, or consumption of caffeine-containing products within 24 hours prior to dosing. 16. Participation in another clinical trial within the past 3 months. 17. Recent or planned surgery within the study period. 18. Receipt of a vaccine within 30 days prior to screening, or a planned vaccine during the study. 19. Blood donation or significant blood loss (≥400 mL) within 1 month prior to screening, or planned blood donation during the study. 20. Inability to tolerate venipuncture for blood collection, or a history of fainting or phobias related to blood draws. 21. Unwillingness to assist with photographic documentation of the application site. 22. Any other condition or circumstance deemed by the investigator to make participation in the study inappropriate.