This study plans to utilize multiphase contrast-enhanced and non-contrast CT(Computed Tomography) images from 10000 pathologically confirmed liver tumor patients at our hospital. An AI(artificial intelligence) model will be used to outline the 3D contours of liver masses, which will then be refined by radiologists and hepatobiliary-pancreatic surgeons to enhance model accuracy. By incorporating more imaging data, the model's recognition capabilities will be improved, laying the groundwork for prospective clinical trials and aiming to establish a superior AI model for early liver cancer screening based on CT imaging.
This research project intends to utilize multiphase contrast-enhanced and non-contrast CT images from 10000 patients with a full spectrum of liver tumors (such as HCC(hepatocellular carcinoma), ICC(intrahepatic cholangiocarcinoma ), META(Metastasis), etc.), confirmed by the pathological gold standard at our hospital. Through a pre-established AI model, the 3D contours of various liver masses will be delineated. In collaboration with senior physicians from our hospital's radiology department and hepatobiliary pancreatic surgery department, the AI-drawn contours will be refined to obtain more accurate 3D mass models, thereby enhancing the validation efficacy of the model. By incorporating more radiological data, the precision of the model will be improved, boosting its recognition capabilities and laying a solid foundation for subsequent prospective clinical trials. The ultimate goal is to establish a superior AI model for early screening of liver cancer based on CTimaging.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
10,000
Using the LIDAR model to assist in image interpretation, patients with positive results are recalled for further examination based on the LIDAR output information and the original image interpretation, to obtain pathological results and long-term follow-up.
the First Affiliated Hospital, School of Medicine, Zhejiang University
Hangzhou, Zhejiang, China
Detection efficiency in liver tumor assisted by LIDAR
Sensitivity、Specificity
Time frame: Complete the statistics within six months after the patient is fully enrolled, and it is expected to take 2 years from the start of the study
Detection efficiency in liver tumor assisted by LIDAR
PPV、NPV
Time frame: Complete the statistics within six months after the patient is fully enrolled, and it is expected to take 2 years from the start of the study
Detection efficiency in liver tumor assisted by LIDAR
AUC
Time frame: Complete the statistics within six months after the patient is fully enrolled, and it is expected to take 2 years from the start of the study
TNM stage
Staging of liver cancer
Time frame: 1 day (evaluate through CT imaging before surgery)
OS
overall survival
Time frame: From diagnosis of liver cancer to 5 years later
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