Efficacy of Zinc Supplementation in Maintaining Sustained Remission in Children With Steroid-sensitive Nephrotic Syndrome

Muhammad Aamir Latif192 enrolled

Overview

This study aims to fill the gaps by determining the efficacy of zinc supplementation in maintaining sustained remission in children with steroid sensitive nephrotic syndrome (SSNS).

There is a need to ascertain the efficacy of zinc supplementation in maintaining sustained remission in children with SSNS, thereby lowering the number of relapses and disease morbidity. The findings of this study could pave the way for reasonable evidence about the role of zinc supplementation is sustained remission in children with SSNS.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

192

Conditions

Steroid-Sensitive Nephrotic Syndrome

Interventions

Zinc supplementation plus standard treatmentDRUG

children were given 5 mg of elemental zinc sulfate as a single daily dose for children less than 4 years of age and 10 mg for children more than 4 years of age for a total duration of 6 months, along with standard therapy.

Eligibility

Sex: ALLMin age: 2 YearsMax age: 12 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Both genders * Aged 2-12 years * With steroid-sensitive nephrotic syndrome, with frequent relapses Exclusion Criteria: * Children with steroid-resistant nephrotic syndrome * With a history of chronic systemic illness (cardiac, metabolic, malignancy, pulmonary, neurologic, or rheumatologic) * With a history of kidney disease like polycystic kidney disease

Locations (1)

Nishtar Hospital

Multan, Punjab Province, Pakistan

Outcomes

Primary Outcomes

Sustained remission

Efficacy yes if sustained remission was seen after the treatment.

Time frame: 6 months

Data from ClinicalTrials.gov

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