A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV

N/ARecruitingNCT06862089

Fu Xing Hospital, Capital Medical University120 enrolled

Overview

The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV). The main question it aims to answer is: Is it possible to achieve the natural resolution of RPOC by combining it with EMV through conservative treatment？ Participants will receive conservative treatment (such as mifepristone, GnRH-a, or expectant management) following the initial diagnosis of RPOC and EMV, and the therapeutic efficacy of the conservative approach will be assessed after the completion of two menstrual cycles.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Retained Products of Conception Miscarriage Conservative Management

Eligibility

Sex: FEMALE

Medical Language ↔ Plain English

Inclusion Criteria: * Recent history of miscarriage or delivery (within the past 8 weeks) * Strong willingness to undergo conservative management * Hemodynamically stable * Signed informed consent form Exclusion Criteria: * Heavy vaginal bleeding (requiring immediate surgical intervention) * Active pelvic or systemic infection (e.g., fever \>38°C, elevated CRP/WBC) * Severe dysfunction of vital organs (heart, liver, or kidney) * Known drug allergies or contraindications to proposed medications (e.g., misoprostol intolerance) * Suspected ectopic pregnancy or gestational trophoblastic disease (confirmed by ultrasound or β-hCG levels) * Placenta accreta spectrum disorders diagnosed during current pregnancy * History of uterine artery embolization

Outcomes

Primary Outcomes

The disappearance rate of RPOC

The definition of "the disappearance rate of RPOC" refers to the absence of significant residual trophoblastic tissue as indicated by ultrasound examination

Time frame: After conservative treatment, transvaginal ultrasound was performed at the end of the second menstrual cycle (calculated from the first day of menses, 28-30 days per cycle) to assess RPOC resolution

Secondary Outcomes

the disappearance rate of EMV

The definition of "the disappearance rate of EMV" refers to a PSV (Peak Systolic Velocity) of less than 20 cm/s or its complete disappearance as indicated by Ultrasound Doppler examination.

Time frame: Immediately after the completion of conservative treatment