The objective of this study is to collect empirical data that elucidates the clinical profile and therapeutic efficacy of benralizumab among the patients aged 12 years and above, with severe eosinophilic asthma. The study will focus on the early treatment response, treatment outcomes and the change in asthma control of benralizumab therapy in a real-world setting in China. This study will also describe the physician-reported reasons for discontinuation and switching of benralizumab therapy.
Study Type
OBSERVATIONAL
Enrollment
1,000
non-interventional
Research Site
Beijing, China
RECRUITINGResearch Site
Binzhou, China
RECRUITINGResearch Site
Guangzhou, China
RECRUITINGResearch Site
Hangzhou, China
RECRUITINGResearch Site
Huzhou, China
RECRUITINGResearch Site
Jinan, China
RECRUITINGResearch Site
Jinhua, China
RECRUITINGResearch Site
Jining, China
RECRUITINGResearch Site
Linyi, China
RECRUITINGResearch Site
Mianyang, China
RECRUITING...and 6 more locations
asthma control questionnaire
To describe the change in asthma control questionnaire at early time point after initiation of benralizumab
Time frame: Week 8
asthma control questionnaire
* Changes from baseline in ACQ-6 at week 1, 2, 4, 16, 24, 40 and 56 after initiation of benralizumab. * The percentage of patients well controlled (defined as ACQ-6 score ≤0.75), partially controlled (defined as ACQ-6 score \>0.75 and \< 1.5) and uncontrolled (defined as ACQ-6 score ≥1.5) at week 1, 2, 4, 8, 16, 24, 40 and 56. * The percentage of patients who had clinically meaningful change of ACQ-6 (defined as at least (≥) 0.5-unit improvement in ACQ-6 score) at the end of treatment at week 1, 2, 4, 8, 16, 24, 40 and 56.
Time frame: week 1, 2, 4, 8, 16, 24, 40 and 56.
changes in lung function
Changes from baseline in pre-BD FEV1 at week 8, 16 and 56 after initiation of benralizumab.
Time frame: week 8, 16 and 56
AstraZeneca Clinical Study Information Center
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