Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.

Meyer Children's Hospital IRCCS90 enrolled

Overview

The proposed study is part of a PNRR 2022 project (call "Non-Communicable Chronic Diseases (NCDs) with high impact on healthcare and social assistance systems," currently awaiting funding response) and represents the continuation of an observational clinical study named TRANSMIC, approved by the pediatric ethics committee of the Tuscany region. TRANSMIC was an integral part of a European research project within the joint programming initiative (JPI), under the HDHL-INTIMIC theme: "A Healthy Diet for a Healthy Life," aimed at understanding the cause-effect relationships between diet, gut microbiome, and human health. Understanding the role of diet in inflammatory bowel diseases (IBD) and exploring its role in autoimmune inflammatory conditions with joint manifestations, such as JIA, provides additional insights into the development, progression, and management of these conditions, opening new horizons for the use of dietary treatments in preventing these inflammatory conditions.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Juvenile Idiopathic Arthritis (JIA)Crohn Disease (CD)Ulcerative Colitis (UC)

Interventions

For each family member will be collected a 3-days food diary, a food frequencies questionnaire and a questionnaire assessing the adherence to the mediterranean diet. Additionally, a blood sample for trascriptomic analysis and a fecal sample for gut microbiota analysis will be collected

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: For families with at least one child/adult affected by IBD/JIA: * Father and mother with children aged between 0-18 years, in good health. * At least one adult or one child affected by IBD, or a child affected by JIA, regardless of ongoing therapy and without distinction of disease severity or activity. For healthy families: \- Father and mother with children aged between 0-18 years, in good health and not affected by chronic inflammatory bowel diseases or chronic autoimmune inflammatory diseases in general. Exclusion Criteria: For subjects affected by IBD: * Monogenic disease * Children with an ileostomy or who have undergone a colectomy For subjects affected by JIA: \- No exclusion criteria For healthy subjects: \- Any chronic inflammatory bowel disease, autoimmune disease, or ongoing infectious diseases.

Locations (4)

AOU Meyer IRCCS

Florence, Italy, Italy

RECRUITING

Università La Sapienza di Roma

Roma, Roma, Italy

RECRUITING

Università di Foggia

Foggia, Italy

RECRUITING

Ospedale Villa Sofia Cervello, Università di Palermo

Palermo, Italy

RECRUITING

Outcomes

Primary Outcomes

3-days food diary, kidmed and medi-lite scores

Time frame: After two weeks

Secondary Outcomes

Percentage of families with microbiota alteration

Time frame: After 6 months

Study on Eating Habits and Association with "omic" Profiles in Families with a Subject Affected by a Chronic Immune-mediated Inflammatory Pathology. Observational Multicenter Study.

Overview

Conditions

Interventions

Eligibility

Locations (4)

Outcomes

Primary Outcomes

Secondary Outcomes

Central Contacts