This study aims to conduct a 8-week intervention involving one formula milk powder for middle-aged and elderly individuals with pre-diabetes, assessing its impact on blood glucose control and fluctuations in comparison to interventions using regular milk powder.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
TRIPLE
Enrollment
110
Fortified formula milk powder is supplemented with fiber, bitter gourd powder,mulberry leaves extract, whitekidney beans extract, and probiotics, and packaged in 25-gram sachets. The milk powder is consumed orally, two sachets per day for a duration of 8 weeks.
Regular milk powder does not contain and additional supplementation, and the color, flavor, shape, taste, and weight are same with the formula milk powder.
fasting blood glucose
At baseline, and 8 weeks, investigators will use automatic electrochemiluminescence analyzer to examine fasting blood glucose.
Time frame: up to 8 weeks
2h-piAUC after standardized breakfast
the positive increment of area under curve in 2 hours after standardized breakfast standardized breakfast, measured by continuous glucose monitoring at baseline, and 8 weeks.
Time frame: up to 8 weeks
TIR (time in range)
TIR refers to the time when blood glucose is controlled within a reasonable ( target ) range (3.9\~10.0 mmol/L), measured by continuous glucose monitoring at baseline and 8 weeks.
Time frame: up to 8 weeks
HbA1c
At baseline, and 8 weeks, investigators will use automatic electrochemiluminescence analyzer to examine HbA1c.
Time frame: up to 8 weeks
weight
At baseline, and 8 weeks, investigators will examine weight.
Time frame: up to 8 weeks
intestinal bacteria
At baseline, and 8 weeks, investigators will use 16S rRNA pyrosequencing to examine intestinal bacteria.
Time frame: up to 8 weeks
lipid metabolism
At baseline, and 8 weeks, investigators will use automatic electrochemiluminescence analyzer to examine total cholesterol, low density lipoprotein, high density lipoprotein, triglyceride.
Time frame: up to 8 weeks
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
sleep quality
At baseline, and 8 weeks, investigators will use the Pittsburgh sleep quality index scale to examine sleep quality.
Time frame: up to 8 weeks
blood pressure
At baseline, and 8 weeks, investigators will test the systolic blood pressure and diastolic blood pressure using automatic digital blood pressure monitor
Time frame: up to 8 weeks
Continuous Glucose Monitoring (CGM) Data
At baseline, and 8 weeks, investigators will using Continuous Glucose Monitoring (CGM) to monitor the glucose level of participants
Time frame: up to 8 weeks