Pressure-enabled Retrograde Occlusive Therapy With Embolization for Control of Thyroid Disease (PROTECT Registry): A Multicenter Registry

Inclusion Criteria: 1. Adults, 18 years and or older and 89 years or younger 2. Having undergone PED-TAE using the TriNav Infusion System 3. Meeting one of the following criteria: 1. Documented subclinical and or clinical hyperthyroidism in the presence of a toxic multinodular goiter or a toxic nodule \> 20 ml 2. Patients' ineligible or refusing surgery, radio-iodine therapy or percutaneous ablation 3. Non-functioning multinodular goiters or nodule causing compressive symptoms including but not limited to neck pain, dysphagia, stridor, exercise induced dyspnea and/or pressure symptoms 4. Bethesda category 2-3 (benign, or atypia or follicular lesion of undetermined significance) on 2 separate fine-needle aspiration biopsy (FNAB) results with a benign molecular profile with patient declining surgical resection Exclusion Criteria: 1. Renal insufficiency 2. Unable to tolerate angiography including pregnancy and severe allergy to contrast media 3. Bethesda 4-6 on FNAB (suspicious for follicular neoplasm, suspicious for malignancy, or malignant) 4. \<18 years old or \>89 years old 5. Graves' disease or inflammatory thyroiditis (Hashimoto's) or other condition with the presence of an extensive collateral network as demonstrated or initial angiography 6. Presence of a bovine arch or any other anatomical variant with no inferior thyroid artery present 7. Prior thyroid thermal ablation