Targeted Decision Making In Renal Cell Carcinoma Relying on a Radiogenomics Translational Platform

IRCCS San Raffaele50 enrolled

Overview

This project aims to provide an accurate strategy to guide the decision making relying on tumor biopsies using standard histology, immunohistochemistry (IHC), spatial transcriptomics, genomics combined with Magnetic Resonance Imaging (MRI) and radiomics. Moreover, the investigators will explore potential markers indicative of response to systemic agents or ablative therapy.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Renal Tumors

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Presence of a renal mass up to 4 cm * Adult \> 18 years * Candidate to renal surgery * Informed consent signed Exclusion Criteria: * Contraindication for MRI

Locations (1)

IRCCS Ospedale San Raffaele

Milan, Italia, Italy

RECRUITING

Outcomes

Primary Outcomes

accuracy of multiparametric preoperative MRI

Detection of "Unfavourable outcome" is defined as the presence of at least one of the following pathological characteristics: * High grade tumor (G3 or G4) * Not-organ confined disease (pT3 and or pT4 and/or LNI) * Sarcomatoid features

Time frame: At final pathological assessment , at least 1 month after surgery

Central Contacts

Umberto Capitanio

CONTACT

3492503788 caitanio.umberto@hsr.it

Data from ClinicalTrials.gov

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