The Myelex study is a fundamental research study that aims to better understand how the brain functions and develops. The objective of this study is to better understand the role of myelin, a sheath that surrounds nerve fibers and determines the speed of information propagation in the brain, in cognitive functioning during development in adolescents and young adults. investigator use Magnetic Resonance Imaging (MRI) because this method allows us to study the anatomy and functioning of the brain in a non-invasive (no injection) and painless manner. investigator focus on cognitive control, a set of cognitive functions in the prefrontal cortex, at the front of the brain, that enable the use of the best strategies on a case-by-case basis to solve problems effectively. These functions are closely associated with academic and professional success and develop late, continuing until early adulthood. The goal of this project is simple: to measure the myelin of nerve fibers using MRI and to evaluate the link with the development of cognitive control. Each participant will undergo an MRI examination and cognitive assessments. The study takes place at the Clinical Research Center of GHU Paris and lasts a total of 3.5 hours, including reception, setup, MRI recording, and the completion of a series of cognitive tasks.
Selection visit * Call for participants for pre-selection * Sending of information forms by mail * Making an appointment for the inclusion visit Inclusion visit at GHU Paris. * Information on the modalities, constraints and foreseeable risks of the study * Collection of informed consent * Verification of inclusion/non-inclusion criteria * Clinical examination: o Verification of medical history and drug treatments * Psychiatric pathology in first-degree relatives * Consumption of toxic substances (nicotine, alcohol, cannabis, etc.) * Manual lateralization will be assessed by the score on the Edinburgh questionnaire (Oldfield, 1971) * Blood sample to measure pubertal hormones (testosterone, estradiol and progesterone levels) * Collection of main medical history and concomitant treatments * Explanation of study procedures * MRI examination * Cognitive assessment
Study Type
OBSERVATIONAL
Enrollment
128
GHU Ste Anne
Paris, France
RECRUITINGMyelin
Myelin Levels : Regional variations of Fractional Anisotropy (FA)
Time frame: Day 1
Working Memory
Spatial Span from CANTAB \- Units on a Scale
Time frame: Day 1
Inhibitory skills
Stop Signal Task from CANTAB and CHEXI, TEXI and ADEXI self-questionnaires \- Units on a Scale
Time frame: Day 1
Planning skills
One Touch Stockings of Cambridge - Units on a Scale
Time frame: Day 1
Decision-making and risk-taking
Cambridge Gambling Task from CANTAB - Units on a Scale
Time frame: Day 1
Reading skills
Text, word and pseudoword reading and metaphonology from EVALEO 6-15/ECLA16+/EXALANG - Units on a Scale
Time frame: Day 1
IQ
Raven's Standard Progressive Matrices (SPM) - Units on a Scale
Time frame: Day 1
Reasoning
Cognitive Reasoning Task - Units on a Scale
Time frame: Day 1
Social Cognition
Tom-15 task - Units on a Scale
Time frame: Day 1
Visuospatial attention
Multiple Object Tracking task from CRAB - Units on a Scale
Time frame: Day 1
Wellbeing questionnaire
KIDSCREEN 27 for minor participants and SF-36 for adults - Units on a Scale
Time frame: Day 1
Behavior questionnaire
BIS/BAS scales - Units on a Scale
Time frame: Day 1
Self-regulation questionnaire
DERS-F - Units on a Scale
Time frame: Day 1
Demographics questionnaire
Age, sex, level of studies, etc.
Time frame: Day 1
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