Chlorhexidine Gluconate Versus Saline for Flushing the Surgical Area During Colorectal Cancer Surgery

Nanchong Central Hospital532 enrolled

Overview

The aim of this study was to compare the effectiveness of chlorhexidine versus saline in flushing the surgical area during colorectal cancer surgery. The primary outcomes included surgical site infection, postoperative complication rates, et al.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

532

Conditions

Colorectal Cancer Surgical Site Infection Chlorhexidine Complications

Interventions

Intraoperative area irrigationPROCEDURE

After colorectal cancer surgery, flush the surgical area with chlorhexidine solution 1 minute before suturing the skin. According to abdominal cavity contamination, bleeding and tumor invasion to determine the flushing time and flush fluid volume. If the abdominal cavity infection is more serious or exudate more, the flushing time can be relatively prolonged. At last, there were no obvious blood residue, tissue fragments and suppurative secretions in abdominal cavity. Ensure that the surgical field of vision is clear, the surface of each organ is smooth, and there is no abnormal exudate.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients aged 18-85 years, 2. Patients with surgically resectable colorectal tumors confirmed by CT/MRI before surgery 3. All patients had a performance status score of 0 or 1 in the Eastern Tumor Cooperative group 4. American Society of Anesthesiology grade I-III Exclusion Criteria: 1. The tumor may have distant metastasis 2. History of previous abdominal surgery 3. The patient has a history of other malignant tumors diagnosed in the past 5 years and has received radiotherapy and chemotherapy in the past 4. There are obvious contraindications to surgery (obvious abnormal liver and kidney function, pregnancy) 5. Participated in other clinical trials within the past 6 months

Locations (1)

Nanchong Central Hospital

Nanchong, Sichuan, China

RECRUITING

Outcomes

Primary Outcomes

Number of participants with Surgical site infection within 30 days

Any surgical site infection within 30 days of surgery is classified as superficial incision, deep mouth, or organ space infection according to the U.S. Centers for Disease Control and Prevention standards.

Time frame: 30 days

Secondary Outcomes

Number of participants with Postoperative complication within 30 days

Including anastomotic fistula, anastomotic hemorrhage, intestinal obstruction, deep vein thrombosis and so on

Time frame: 30 days

Data from ClinicalTrials.gov

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