The Effect of Probiotic and Prebiotic Supplementation on Gastrointestinal Health in Individuals With Chronic Spinal Cord Injury

Inclusion Criteria (at screening): * Age: ≥ 18 years * Sex: male and female. * Chronic SCI (\>1 year post-injury) * Individuals with para- and tetraplegia (American Spinal Cord Injury (ASIA) Impairment Scale (AIS) score A-D) * Having significant gastrointestinal complaints, indicated with "yes" at screening and by a GIQLI questionnaire score below 110 at baseline * Signed written informed consent Exclusion Criteria (at screening): * Antibiotic use within the last four weeks before starting the study * Major dietary changes within the last four weeks before starting the study, such as initiating a vegan or ketogenic diet * Presence of clinically relevant medical conditions, including Crohn's disease, diagnosed eating or gastrointestinal disorders, assessed on an individual basis * Intake of significant concomitant medication, including immunomodulating therapy, mesalazines, or steroids, assessed on an individual basis * Concurrent participation in other clinical trials investigating or potentially affecting GI health * Insufficient German language skills to follow the study procedures * Pregnancy (anamnestic)