Impact of Sarcopenia on Dyspnea in Patients With Asthma

N/ANot Yet RecruitingNCT06870890

University Hospital, Clermont-Ferrand100 enrolled

Overview

Dyspnea in asthma, is mainly due to airway obstruction but can be caused by several alternative diagnoses. The impact of sarcopenia on dyspnea in patients with asthma is unknown. Sarcopenic asthma had a reduced physical activity and is associated with airway obstruction compared to non-sarcopenic asthma. In patients with obstructive pulmonary disease, sarcopenia is associated with shallow breathing and diverse sensory and affective components of exertional dyspnea . The morbidity of sarcopenia is also increased by systemic inflammation and the production of inflammatory cytokines as found in inflammatory airway obstruction. The investigators will investigate the prevalence and impact of sarcopenia in asthmatics patients. This will enable to better manage sarcopenia in asthmatic patients, understand its origins and personalize treatment.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

100

Conditions

Sarcopenia Asthma Dyspnea Dyspnea; Asthmatic

Interventions

muscle evaluationDIAGNOSTIC_TEST

The investigators will evaluate the muscle mass and muscle strenght for all patients included

DosageBIOLOGICAL

Evaluation of the cinetic of biomarkers during exercise

Cardiopulmonary exercise testDIAGNOSTIC_TEST

CPET

Questionnaire and Physical ExamCOMBINATION_PRODUCT

Evaluating dyspnea, anxiety, sleep, physical activity, quality of life

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * Patient affiliated to a social security scheme. * Patient capable of giving free, informed, written and signed consent. * Asthmatic patients with a diagnosis made by a pulmonologist on GINA level 4 or 5 treatment * ACT asthma control score \< 20 * Patient judged by the investigator to be able to to perform a maximal exercise test. Exclusion Criteria: * Patient under guardianship/trusteeship/supervision of justice * Pregnant or breast-feeding women * Unstable heart disease * Patients who have been smoking or have stopped smoking for less than 5 years,

Outcomes

Primary Outcomes

Variation in the intensity of dyspnea during exercise mesured with Borg scale (0-10) according to the presence of sarcopenia

Recording of Borg's dyspnea score during exercise on a scale of 0 (no dyspnea) to 10 (major dyspnea)

Time frame: From baseline (at rest) to the end of the exercise

Secondary Outcomes

Variation in exercise-induced release of biomarkers according to the presence of sarcopenia

Variation of cytokine as IL-1, IL-6, IL-8, IL-10 and TNF-alpha plasma concentrations (pg/mL) ; adipokines ; myokines

Time frame: at rest = baseline / right after the end of exercice / 45 minutes after the end of exercice

Difference in muscle mass (kg) on impedancemetry according to the presence of sarcopenia

Time frame: Baseline

Difference on maximum aerobic capacity (VO2 max in L/mn) , according to the presence of sarcopenia

Difference on physical activity

Time frame: immediately after the exercise test

Difference in fat mass (kg) on impedancemetry according to the presence of sarcopenia

Time frame: At baseline