Emotional dysregulation (ED) is defined as difficulties in modulating the experience and expression of emotions, which are characterized by a particularly marked reactivity, intensity and duration. In order to improve the understanding of ED, its consequences in autistic women, and to be able to offer them appropriate treatments, it seems crucial to investigate the links between ED, adversities experienced during childhood and premenstrual dysphoric symptoms. This study aims to characterize the variability of ED along a menstrual cycle by measuring it in a real-life ecological context. The variability of ED will be compared to that of women with borderline personality disorder BPD and that of women without psychiatric disorders.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
NONE
Enrollment
70
Structured Clinical Interview for DSM-5 Personality Disorder (SCID) : The SCID is a 90-item semi-structured interview, covering all 10 categories of personality disorder as described in the DSM-5. Each item is rated on a three-point scale: "absent", "subclinical level" and "present".
Participants will complete a battery of self-report questionnaires, assessing emotional dysregulation (including SRD, the primary endpoint), childhood adversity, anxiety, depression, and premenstrual symptoms.
Cognitive assessment, coupled with the recording of physiological parameters (Biopac). Participants will complete a battery of neuropsychological tests targeting emotional processes. These tests will make it possible to evaluate the hot component of executive functioning, i.e. specifically involved in the processing of socio-emotional information. Autobiographical verbal fluences and the emotional Hayling test will be used to measure initiation and inhibition processes, respectively.
A momentary ecological evaluation protocol will be proposed between visits V1 and V4 in order to assess the emotional and symptomatic dynamics in a context of daily life. During two menstrual cycles, subjects will be invited, via their smartphone, to take daily semi-random readings (indicated by SMS) of their subjective (4 times/day), but also spontaneous emotional experiences
The links between emotional dysregulation and premenstrual dysphoric symptoms in autistic women compared to women with borderline personality disorder and women without a diagnosed psychiatric disorder (healthy volunteers).
Comparison between groups (autistic people, people with BPD, people without disorders) of the intensity of ED assessed using self-report questionnaires according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase).
Time frame: 3 months
The impact of the menstrual cycle on emotional manifestations
Correlation and mediation between scores on the emotional dysregulation (Emotional Regulation Scale 16, Shortened Scale of Emotional Dysregulation, Alexithymia Scale, Flexible Regulation of Emotional Expression Scale), childhood adversity and premenstrual dysphoric symptoms scales and Daily recording of the intensity of difficulties.
Time frame: 3 months
The impact of the menstrual cycle on cognitive manifestations
Correlation and mediation between scores on the emotional dysregulation (Emotional Regulation Scale 16, Shortened Scale of Emotional Dysregulation, Alexithymia Scale, Flexible Regulation of Emotional Expression Scale), childhood adversity and premenstrual dysphoric symptoms scales and Daily recording of the intensity of difficulties.
Time frame: 3 months
The impact of the menstrual cycle on behavioral manifestations
Correlation and mediation between scores on the emotional dysregulation (Emotional Regulation Scale 16, Shortened Scale of Emotional Dysregulation, Alexithymia Scale, Flexible Regulation of Emotional Expression Scale), childhood adversity and premenstrual dysphoric symptoms scales and Daily recording of the intensity of difficulties.
Time frame: 3 months
Subjective differences in real-life emotional experience between ASD, BPD, and healthy volunteers
Premenstrual dysphoric symptoms scores
Time frame: 3 months
Cognitive correlates of emotional dysregulation by phase of the menstrual cycle
Comparison of Suicidal Ideation Scale scores in the follicular, luteal, and mid-luteal phases of the menstrual cycle
Time frame: 3 months
The concordance between subjective, physiological and cognitive measures of emotional dysregulation, assessed in daily life, in ASD, BPD and healthy volunteers
Comparison of scores on the scales assessing emotional dysregulation, List of Borderline Symptoms 23, autistic traits (AQ), Depression, Anxiety and Stress Scale (EDAS-21) and depressive traits (EDAS-21, BDI) in the follicular phase and the late luteal phase of the menstrual cycle.
Time frame: 3 months
The concordance between cognitive and physiological measures of emotional dysregulation, assessed in consultation, in autistic people compared to people with BPD and healthy volunteers
Comparison of the frequency of emotional responses observed in a real-life context (ecological momentary assessment - EMA, according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
The association between subjective and cognitive measures of emotional dysregulation, assessed in consultation, in ASD compared to BPD and healthy volunteers
Comparison of the skin conductance recorded by the Empatica connected watch according to the phase of the cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
Evaluate the intensity of dysphoric symptoms during two menstrual cycles
Comparison of performance at the proposed emotional Stroop task in daily life according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase
Time frame: 3 months
Understand the impact of these dysphoric symptoms during two menstrual cycles
Comparison of performance at the proposed emotional Stroop task in daily life according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase
Time frame: 3 months
The evolution of self-reported emotional dysregulation assessed in daily life during two menstrual cycles
Comparison in the follicular phase and in the late luteal phase of performances in the emotional Hayling.
Time frame: 3 months
The evolution of the emotional experience, assessed in daily life, during two menstrual cycles
Comparison of the evolution of the emotional experience between the three groups (autistic women, women with borderline personality disorder and control group
Time frame: 3 months
The evolution of physiological emotional responses, assessed in daily life and in consultation, during two menstrual cycles
Comparison of the evolution of physiological emtional reponses between the three groups (autistic women, women with borderline personality disorder and control group)
Time frame: 3 months
The evolution of cognitive functioning underlying emotional dysregulation, over the course of two menstrual cycles
Comparison of the evolution of cognitive functioning underlying emotional dysregulation between the three groups (autistic women, women with borderline personality disorder and control group)
Time frame: 3 months
The concordance between cognitive and physiological measures of emotional dysregulation, assessed in consultation, in autistic people compared to people with BPD and healthy volunteers
Comparison of the intensity of emotional responses observed in a real-life context (ecological momentary assessment - EMA, according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
The concordance between cognitive and physiological measures of emotional dysregulation, assessed in consultation, in autistic people compared to people with BPD and healthy volunteers
Comparison of the variability of emotional responses observed in a real-life context (ecological momentary assessment - EMA, according to the phase of the menstrual cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
The association between subjective and cognitive measures of emotional dysregulation, assessed in consultation, in ASD compared to BPD and healthy volunteers
Comparison of the body temperature recorded by the Empatica connected watch according to the phase of the cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
The association between subjective and cognitive measures of emotional dysregulation, assessed in consultation, in ASD compared to BPD and healthy volunteers
Comparison of the heart rate) recorded by the Empatica connected watch according to the phase of the cycle (follicular phase, luteal phase and late luteal phase)
Time frame: 3 months
The evolution of self-reported emotional dysregulation assessed in daily life during two menstrual cycles
Comparison in the follicular phase and in the late luteal phase of performances in a negative priming task.
Time frame: 3 months
The evolution of self-reported emotional dysregulation assessed in daily life during two menstrual cycles
Comparison in the follicular phase and in the late luteal phase of performances in a heart rhythm detection task proposed for consultation.
Time frame: 3 months
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