Acute kidney injury (AKI) is one of the most frequent major complications in patients undergoing cardiac surgery. CSA-AKI is independently related to increased perioperative mortality, increased hospital and ICU length of stay as well as heath care expenditure. Identification of relevant biomarkers may lead to early diagnosis and improve patient outcomes and health care costs. The pathophysiology of CSA-AKI is complex and ischemia-reperfusion injury is one of the important factors. Recently, it has been shown that Tissue Inhibitor of Metalloproteinases 2 (TIMP2) is associated with ischemia-reperfusion injury. In this study, relationship between TIMP2 with the risk of CSA-AKI was analyzed and the predictive value of elevated level of TIMP2 for early prediction of CSA-AKI was further evaluated.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
OTHER
Masking
QUADRUPLE
Enrollment
100
different TIMP2 level after on-pump cardiac surgery
Zhongnan Hospital
Wuhan, Hubei, China
the development of CSA-AKI
the development of CSA-AKI
Time frame: 1 Week
AKI severity
AKI stage 1，stage 2，stage 3
Time frame: 1 Week
need for RRT
Reflect kidney function
Time frame: 1 Week
duration of AKI (≥7 days)
Reflect kidney function
Time frame: 1 Week
length of ICU stay
Reflect patient prognosis
Time frame: up to 28 days
post-operative hospital stay
Reflect patient prognosis
Time frame: up to 28 days
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