Analysis of the Levels of HLADR+ Extracellular Vesicles in Women With Preeclampsia as a Early Potential Biomarker

N/AActive Not RecruitingNCT06873737

Fondazione Policlinico Universitario Agostino Gemelli IRCCS300 enrolled

Overview

Analysis of the circulating levels of placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia.

The aim of this study is to analyze the levels of circulating placenta-derived HLA-DR+ extracellular vesicles in the first, second and third trimester of pregnancy of women with high and low risk to develop preeclampsia to investigate the potential role of HLA-DR as early biomarker.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

300

Conditions

Preeclampsia

Interventions

Blood samples for inflammatory markersOTHER

Blood sampling in the first, second, trimester of pregnancy

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Pregnant Women * Aged \> 18 years Exclusion Criteria: * age \< 18 years * women unable to give informed consent * infectious diseases * twin pregnancies

Locations (1)

Fondazione Policlinico Universitario Agostino Gemelli

Rome, Italy

Outcomes

Primary Outcomes

Levels of circulating HLA-DR+ extracellular vesicles

Levels of circulating HLA-DR+ extracellular vesicles during pregnancy

Time frame: During the first trimester of pregnancy (11-13 weeks +6 days of gestational age), the second trimester (19-22 weeks of gestation) and the third trimester (28-32 weeks of gestation) of pregnancy

Data from ClinicalTrials.gov

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