The goal of this observational study is to learn if clinical and neurophysiological characteristics dynamics may follow similar trends in a longitudinal characterization of patients with a diagnosis of an eating disorder. The primary hypothesis is that the reversal of Functional Magnetic Resonance Imaging (fMRI) baseline alternations is positively associated with symptomatic amelioration. The secondary hypothesis is that the degree of (f)MRI baseline alternations is positively associated with symptoms. Participants will be asked to complete psychometric questionnaires, perform a fMRI and be recalled at 12 months for a follow-up.
Study Type
OBSERVATIONAL
Enrollment
50
structural and functional MRI
Azienda Ospedaliero-Universitaria Careggi, Firenze
Florence, Italy
RECRUITINGMeyer Children's Hospital IRCCS
Florence, Italy
RECRUITINGChange in cortical thickness
Time frame: baseline, 12 months post-enrollment
Weight restoration
Time frame: baseline - 12 months post-enrollment
Child Behavior Checklist (CBCL) score
Time frame: Baseline - 12 months post enrollment
Children's Depression Inventory (CDI) score
Time frame: baseline, 12 months post-enrollment
Multidimensional Anxiety Scale for Children (MASC)
Time frame: Baseline - 12 months post-enrollment
Eating Disorder Inventory (EDI) psychometric score
Time frame: Baseline - 12 months post-enrollment
Change of measure of interhemispheric connectivity between corresponding areas in fMRI (Voxelwise Homotopic Connectivity - VMHC)
VMHC is a measure of interhemispheric connectivity between corresponding areas in fMRI. VMHC measures the level of symmetry, or correlation, between left/right pairs of voxels or brain areas.
Time frame: baseline, 12 months post-enrollment
Change in Regional Homogeneity (ReHo) index
Time frame: baseline, 12 months post-enrollment
Chiange in amplitude of low-frequency fluctuations (ALFF) and fractional amplitude of low-frequency fluctuations (fALFF) of the blood oxygen-level dependent (BOLD) signal in fMRI data
Time frame: baseline, 12 months post-enrollment
Change in connection degree between each node and other nodes (Degree of Centrality - DC) in the network in the brain.
Time frame: Baseline - 12 months post-enrollment
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