Thromboembolic And Bleeding Risks During anticoaGulant trEatment in Asian paTients With Atrial Fibrillation (TARGET-AF)

N/AEnrolling By InvitationNCT06874894

Chung-Ang University Hosptial, Chung-Ang University College of Medicine1,021 enrolled

Overview

This study was design to investigate the efficacy and safety of NOAC therapy in Koreans

East Asians have demonstrated a higher bleeding tendency compared to Western populations during an anticoagulation. Consequently, East Asians have been prescribed as a relatively weaker treatment regimens based on this evidence. Therefore, the TARGET-AF study aims to verify the efficacy and safety of NOAC therapy using biomarkers including TEG®-6S point-of-care device in Koreans

Study Type

OBSERVATIONAL

Enrollment

1,021

Conditions

Fibrillation, Atrial

Eligibility

Sex: ALLMin age: 18 Months

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with documented AF on 12-lead ECG, Holter monitoring, or single-lead ECG recordings are eligible for enrollment. * Based on AF treatment Korean guideline 19, AF patients who require NOAC treatment or are currently on NOAC treatment (within the past 3 months) * Adults aged 18 or above who have provided consent for clinical information Exclusion Criteria: * Patients with moderate or severe mitral stenosis or mechanical prosthetic valve

Locations (2)

Chung-Ang University Gwangmyeong Hospital

Gwangmyeong, South Korea

Chung-Ang University Hospital

Seoul, South Korea

Outcomes

Primary Outcomes

Clinical ischemic and hemorrhagic events

The Rate of Ischemic stroke, systemic embolism, or myocardial infarction and ISTH (International Society on Thrombosis and Hemostasis) major/minor bleeding events

Time frame: 12 months

Secondary Outcomes

Clinical other events

The rate of Major Adverse Cardiovascular Events: Myocardial infarction, ischemic stroke, systemic embolism, and cardiovascular death (including bleeding).

Time frame: 12 months

Data from ClinicalTrials.gov

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