Nanobody-Based Anti-CD5 CAR-T for Relapsed/Refractory T-ALL/LBL

Inclusion Criteria: 1. The subject or guardian understands and voluntarily signs the informed consent form (ICF). 2. Male or female, aged 3-70 years at the time of signing the ICF (inclusive). 3. Expected survival of at least 12 weeks. 4. ECOG performance status of 0-2 at the time of ICF signing. 5. Diagnosis of relapsed/refractory T-cell lymphoblastic leukemia/lymphoma (R/R T-ALL/LBL) confirmed at screening and meeting at least one of the following criteria: 1. Bone marrow involvement: Morphologic examination shows ≥5% lymphoblasts, and/or 2. Cerebrospinal fluid (CSF) involvement: Tumor cells detected in CSF, and/or 3. Extramedullary disease: Presence of measurable lesions (lymph node/mass ≥1.5 cm in axial diameter or extranodal lesion ≥1 cm in axial diameter). 4. CD5 expression: Tumor cells in bone marrow, peripheral blood, or CSF are CD5-positive by flow cytometry, and/or lymph node/mass or extranodal lesions are CD5-positive by pathology. 6. Adequate major organ function, defined as: 1. AST and ALT ≤5× upper limit of normal (ULN). 2. Total bilirubin ≤2× ULN. 3. Renal function: Serum creatinine clearance ≥60 mL/min (Cockcroft-Gault formula) or creatinine ≤1.5× ULN. 7. Blood oxygen saturation \>92%. 8. Reproductive health requirements: * Fertile men and women of childbearing potential must agree to use effective contraception from ICF signing until 2 years after study drug administration. * Women of childbearing potential (pre-menopausal or within 2 years post-menopause) must have a negative blood pregnancy test at screening. Exclusion Criteria: 1. History of central nervous system (CNS) diseases, including but not limited to: * Epilepsy * Paralysis * Aphasia * Stroke * Severe brain injury * Dementia * Parkinson's disease * Neuropathy 2. History of autoimmune diseases requiring systemic immunosuppressive therapy within 2 years prior to signing the ICF, including but not limited to: * Crohn's disease * Rheumatoid arthritis * Systemic lupus erythematosus (SLE) * Systemic sclerosis * Inflammatory bowel disease (IBD) * Vasculitis * Psoriasis 3. Presence of any uncontrolled active infection at the time of signing the ICF or within 4 weeks prior to apheresis that requires antibiotic, antiviral, or antifungal treatment. 4. Positive virological or infectious disease markers, including: * Hepatitis B virus (HBV): Subjects with positive HBsAg or HBcAb-positive at screening must have undetectable HBV DNA in peripheral blood to be eligible; otherwise, they should be excluded. * Hepatitis C virus (HCV): Subjects with positive HCV antibodies and detectable HCV RNA should be excluded. * Human immunodeficiency virus (HIV) antibody-positive subjects should be excluded. * Cytomegalovirus (CMV) DNA test-positive subjects should be excluded. * Epstein-Barr virus (EBV) DNA test-positive subjects should be excluded. * Positive serological or non-specific antibodies for Treponema pallidum (syphilis). 5. Clinically significant cardiovascular diseases, including any of the following: 1. QTc interval ≥480 ms (Fridericia correction formula) 2. New York Heart Association (NYHA) Class II or higher heart failure 3. Unstable angina or acute myocardial infarction within 6 months prior to signing the ICF 4. Left ventricular ejection fraction (LVEF) \<50% 5. Poorly controlled hypertension (as determined by the investigator) 6. Clinically significant arrhythmias or those requiring antiarrhythmic treatment, including: * Persistent ventricular tachycardia * Ventricular fibrillation * Torsades de pointes * Complete left bundle branch block 6. History of severe hypersensitivity or allergy to any components of the study drug. 7. Receipt of any investigational drug therapy or other systemic antitumor therapy within 4 weeks before apheresis (or 5 half-lives of the drug, whichever is longer, as determined by the investigator). 8. Receipt of extensive radiotherapy within 4 weeks prior to signing the ICF, except for palliative radiotherapy for non-target lesions within 2 weeks before signing the ICF or as expected during the study. 9. Unresolved toxicity from prior antitumor therapy that has not returned to Grade 1 or baseline levels at the time of signing the ICF, except for hair loss and pigmentation (per NCI-CTCAE v5.0). 10. Requirement for systemic corticosteroids or other immunosuppressive therapy (≥10 mg/day prednisone or equivalent) within 3 days prior to apheresis or during the study period, except for: 1. Intranasal, inhaled, or topical steroids, or localized steroid injections (e.g., intra-articular injections) 2. Systemic corticosteroids ≤10 mg/day prednisone (or equivalent physiological dose) 3. Steroids as prophylaxis for allergic reactions (e.g., pre-medication before contrast-enhanced CT) 4. Steroids used for symptomatic treatment of transfusion-related reactions 11. Major surgery within 4 weeks prior to signing the ICF (excluding routine biopsy procedures) or planned major surgery during the study period. 12. History of active tuberculosis infection within 1 year prior to signing the ICF, except for subjects with a history of tuberculosis more than 1 year ago, provided that the investigator determines there is no evidence of active tuberculosis. 13. History of other primary malignancies within 5 years prior to signing the ICF, except for: 1. Adequately treated carcinoma in situ of the cervix 2. Localized basal cell carcinoma or squamous cell carcinoma of the skin 14. Receipt of live-attenuated or inactivated vaccines within 4 weeks before signing the ICF or planned vaccination during the screening period. 15. Any other condition or complication that, in the investigator's judgment, may affect adherence to the study protocol or make the subject unsuitable for participation. 16. Pregnancy or lactation.