Prostaglandin Analog Eyelash Serum and Ocular Surface Health: A Prospective Study

University of Seville19 enrolled

Overview

This prospective interventional study investigates the effects of a prostaglandin analog-based eyelash serum on ocular surface integrity, tear film stability, and eyelash growth over six weeks. Nineteen healthy female participants applied the serum daily, with clinical assessments performed at baseline and post-treatment. The study adhered to ethical guidelines, and parameters such as tear film stability, tear volume, ocular hyperemia, and eyelash characteristics were evaluated.

Study Type

INTERVENTIONAL

Allocation

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Enrollment

Conditions

Dry Eye

Interventions

Prostaglandin Analog-Based Eyelash SerumOTHER

This intervention consists of a prostaglandin analog-based eyelash serum applied once daily to the upper eyelid margin for six weeks. The serum contains dechloro dihydroxy difluoro ethylcloprostenolamide (DDDE), a prostaglandin analog known to promote eyelash growth. The formulation also includes panax ginseng root extract, urtica dioica extract, panthenol, niacinamide, and biotinoyl tripeptide-1, which contribute to hair follicle nourishment. The study evaluates its effects on ocular surface integrity, tear film stability, and eyelash growth.

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 30 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Female individuals aged 18 to 30 years. * Corrected distance visual acuity (CDVA) of 0.10 LogMAR or better in both eyes. * Fitzpatrick skin type III or lower. * No active dermatological conditions affecting the periocular area. * Regular use of cosmetic products (e.g., mascara, eyeliner, or eyeshadow) with no history of intolerance. * Willingness and ability to follow the serum application protocol for six weeks. Exclusion Criteria: * History or diagnosis of dry eye disease or other ocular surface disorders. * Previous ocular surgery, trauma, or systemic conditions affecting ocular surface function. * Use of topical or systemic medications that could impact tear film stability. * Documented hypersensitivity or allergic reactions to cosmetic or ophthalmic products. * Presence of eyelid disorders that could interfere with eyelash growth (e.g., blepharitis, trichiasis). * Use of growth-enhancing serums within the past three months. * Pregnancy or breastfeeding at the time of enrollment.

Locations (1)

University of Seville

Seville, Spain

Outcomes

Primary Outcomes

Change in Tear Film Stability (A-NIBUT) After Six Weeks of Eyelash Serum Application

Assessment of average non-invasive tear break-up time (A-NIBUT) as an indicator of tear film stability before and after six weeks of daily prostaglandin analog-based eyelash serum application. A-NIBUT is measured using the Firefly S390I slit lamp (MediWorks, Suzhou, China), with lower values indicating increased tear film instability.

Time frame: Baseline and after six weeks of serum application

Secondary Outcomes

Change in Tear Volume (Tear Meniscus Height - TMH) After Six Weeks

Measurement of tear meniscus height (TMH) before and after six weeks of eyelash serum application using the Firefly S390I slit lamp to assess changes in aqueous tear volume. Lower TMH values indicate a reduction in tear production.

Time frame: Baseline and after six weeks

Change in Ocular Hyperemia (Conjunctival and Ciliary Hyperemia) After Six Weeks

Evaluation of temporal conjunctival hyperemia (TCOH) and temporal ciliary hyperemia (TCIH) using digital image analysis. An increase in hyperemia suggests a vasodilatory response to the serum.

Time frame: Baseline and after six weeks

Change in Eyelash Length and Thickness After Six Weeks

Measurement of eyelash length and thickness before and after six weeks using caliper software on the Firefly S390I slit lamp to determine the efficacy of the serum in promoting eyelash growth.

Time frame: Baseline and after six weeks

Data from ClinicalTrials.gov

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