EVALUATION of GINGIVAL CREVICULAR FLUID and SERUM ASPROSIN LEVELS in OBESE and NORMAL-WEIGHT INDIVIDUALS with PERIODONTITIS

Inclusion Criteria: 1. Willingness to participate in the study. 2. Weight classification: * Obese individuals: Body mass index (BMI) of 30 kg/m² or higher. * Normal-weight individuals: BMI between 18.5 and 24.9 kg/m². 3. Periodontal health status: * Bleeding on probing: less than 10%. * Periodontal pocket depth: less than 3 mm. * No sites showing attachment loss or alveolar bone loss on radiographs. 4. For individuals with periodontitis: * At least two non-adjacent teeth must show signs of interdental attachment loss. * Periodontal pocket depth greater than 3 mm. Exclusion Criteria: 1. Individuals who have received periodontal therapy, any oral decontamination treatment, or antibiotics or steroids in the six months prior to the start of the study. 2. Individuals who are pregnant or breastfeeding. 3. Individuals diagnosed with rheumatoid arthritis or lupus erythematosus. 4. Individuals with a medical history of radiation or cancer therapy. 5. Patients with diabetes, defined by: * Hemoglobin A1c (HbA1c) level greater than 6.5%. * Fasting blood glucose (FBG) greater than 126 mg/dL. * An abnormal oral glucose tolerance test (OGTT). 6. Smokers.