Two combination interventions (HIV Case Finding Intervention and HIV Treatment Intervention), each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials among youth aged 15-24 in Nigeria.
Two combination interventions, each with mHealth and Peer Navigation components, will be evaluated in two 48-week parallel hybrid effectiveness/implementation trials among youth aged 15-24 in Nigeria: 1. HIV Case Finding Intervention: single arm trial of an HIV case finding and linkage to care intervention targeting young men at risk of HIV infection (n = 6000), particularly young men who have sex with men (YMSM) in Akwa Ibom, Benue, Enugu, Kano, Taraba, and Lagos states who complete HIV testing. Objectives: To determine the effectiveness of the intervention to: * identify youth living with HIV, particularly YMSM and * link those who test HIV-positive to HIV care * pre-exposure prophylaxis (PrEP) initiation (uptake) among those who test HIV-negative. 2. HIV Treatment Intervention: randomized controlled trial of a medication adherence and viral suppression intervention among youth newly diagnosed with HIV and initiating antiretroviral therapy (ART) for the first time (n = 600) at the participating clinical sites. Objectives: To determine the effectiveness of the intervention on * viral suppression and * adherence to ART * success of implementation in the target populations
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Enrollment
500
Peer navigators will promote HIV testing in YMSM and linkage to care if HIV-positive
Motivational-interviewing to promote uptake of PrEP among those who test HIV-negative
Peer navigators will provide assistance and support to youth with HIV to optimize adherence to ART
University of Uyo Teaching Hospital
Uyo, Akwa Ibom State, Nigeria
RECRUITINGFederal Medical Center
Makurdi, Benue State, Nigeria
RECRUITINGUniversity of Nigeria Teaching Hospital
Enugu, Enugu State, Nigeria
Case Finding: HIV-positive serostatus
HIV-positive serostatus based on rapid test with confirmation
Time frame: 48 weeks
Treatment: Viral suppression
Viral suppression (\< 200 copies per mL)
Time frame: 48 Weeks
Case Finding: Linkage to HIV care
Linkage to HIV care within 30 days of positive HIV test
Time frame: 48 Weeks
Case Finding: PrEP among youth who test HIV-negative
PrEP uptake among youth who test HIV-negative
Time frame: 48 weeks
Treatment: Adherence to antiretroviral therapy (ART)
\> 90% adherence to ART
Time frame: 48 Weeks
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Social media outreach to identify youth at risk for HIV
Text (SMS) messages to remind and encourage youth to adhere to their ART
Standard of care HIV treatment adherence
Aminu Kano Teaching Hospital
Kano, Kano State, Nigeria
RECRUITINGLagos University Teaching Hospital
Lagos, Lagos, Nigeria
RECRUITINGTaraba State Specialist Hospital
Jalingo, Taraba State, Nigeria
RECRUITING