Ultrasound Acute Chest Syndrome Sickle Cell Disease

Indiana University27 enrolled

Overview

Feasibility and reliability of ultrasound in the inpatient hematology setting.

Acute chest syndrome (ACS) is a complication of sickle cell disease where individuals have symptoms of fever, low oxygen levels or difficulty breathing in the setting of a new lung finding on chest x-ray. Chest x-ray is a useful tool to identify it but has some side effects. The investigators think ultrasound will be an equally feasible, reliable tool and minimize some of the side effects associated with chest x-ray. Ultrasound is a non-invasive was to obtain an image that does not require radiation.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Conditions

Acute Chest Syndrome Sickle Cell Disease

Interventions

Point of Care UltrasoundDEVICE

Point of Care Ultrasound during hospitalization

Eligibility

Sex: ALLMax age: 25 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age: 0-25 years old 2. Diagnosis: Patients with a documented diagnosis of sickle cell disease (any genotype) 3. Disposition: Hospitalized for a SCD-related complication (e.g. VOC) Exclusion Criteria: 1. Patient is considered hemodynamically unstable to undergo consent and study procedures 2. Already has diagnosis of ACS prior to admission to inpatient unit 3. POCUS operator not available

Locations (1)

Indiana University

Indianapolis, Indiana, United States

Outcomes

Primary Outcomes

Participation rate

Percentage of patients who are approached for study who agree to be on study

Time frame: Up to 5 days

Retention rate

Percentage of patients who remain on study

Time frame: Up to 5 days

Duration of exam

Time taken to complete POCUS examination

Time frame: Up to 5 days

Acceptability of POCUS by the medical team (physicians and nursing)

Acceptability measured using a 5-point Likert Scale (Strongly Agree to Strongly Disagree) regarding use of POCUS in inpatient setting.

Time frame: Up to 5 days

Secondary Outcomes

Reliability of point of care ultrasound (POCUS) compared to standard of care (Chest X-ray)

A positive screening of acute chest syndrome by POCUS is identification of either a lung consolidation or focal B-lines. POCUS findings will be compared to standard of care (Chest X-ray) findings to see if findings concur.

Time frame: Up to 5 days

Data from ClinicalTrials.gov

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