This is a multicenter, randomized, open-label, parallel-controlled, prospective clinical study. It aims to evaluate the efficacy and safety of aerosolized Peginterferon α-2b injection in the treatment of pediatric respiratory syncytial virus pneumonia. The overall study is divided into a screening period, a treatment period, and a follow-up period. Eligible children with respiratory syncytial virus pneumonia will be randomly assigned to the experimental group 1, experimental group 2, and the control group at a ratio of 1:1:1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
90
Peginterferon α-2b injection, 45 mcg, neb.On the 1st, 3rd, and 5th day, take the medication,while providing symptomatic and supportive treatment simultaneously.
Peginterferon α-2b injection, 90 mcg, neb.On the 1st, 3rd, and 5th day, take the medication,while providing symptomatic and supportive treatment simultaneously.
symptomatic and supportive treatment
Chengdu Women's and Children's Central Hospital
Chengdu, Sichuan, China
RECRUITINGWest China Second University Hospital of Sichuan University
Chengdu, Sichuan, China
RECRUITINGTime for the disappearance of major clinical symptoms
Major clinical symptoms include fever, cough, wheezing, increased respiratory rate, and moist rales in the lungs
Time frame: Day 6
The time of disappearance of abnormal signs.
Abnormal signs include fever, cough, wheezing, increased respiratory rate, and moist rales in the lungs.
Time frame: Day 6
Compare the differences in treatment efficacy rates among the various groups.
Time frame: Day 6
Compare the differences in the proportions of primary clinical symptoms alleviated/disappeared among the various groups.
Time frame: Day3,5.
Compare the differences in the proportions of abnormal physical signs alleviated or disappeared among the various groups.
Time frame: Day3,5.
Compare the differences in the time curves for the normalization of major clinical symptoms among the various groups.
Time frame: Day6
Compare the differences in the time curves for the normalization of major abnormal physical signs among the various groups.
Time frame: Day6
Compare the differences in total hospitalization duration among the various groups.
Time frame: Day6
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