The goal of this observational retrospective study is to assess the impact of hepatitis B virus (HBV) infection on the clinical course and outcomes of inflammatory bowel disease (IBD) in Egyptian patients. Researchers will compare the IBD extent, location, severity, and behavior between IBD patients with and without HBV infection. Participants will be subjected to history-taking (history of hospital admission and disease flare, surgical history, medication history, follow-up duration, and mortality), clinical examination, laboratory investigations, abdominal ultrasonography, and endoscopic examination.
Study Type
OBSERVATIONAL
Enrollment
162
Full history taking including: * Personal history (name, age, sex, occupation, residence, and marital state). * Complaint. * Age at diagnosis of IBD. * Medication history. * History of hospital admissions and disease flares. * Disease extent, location, and behavior. (Montreal classification, Truelove-Witts severity index). * Surgical history (intestinal resection in CD patients and total proctocolectomy in UC patients). * Follow up duration and mortality. * Data of endoscopic examination * Data of laboratory investigations (complete blood picture, HBV serology, liver and kidney function tests, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)).
Tanta University Hospitals
Tanta, Gharbyea, Egypt
RECRUITINGNumber of patients with severe IBD measured by Truelove-Witts severity index
comparing IBD extent, location, and behavior using Montreal classification, Truelove-Witts severity index between patients with and without HBV infection
Time frame: through study completion, an average of 6 month
Hospital admission rates in IBD patients
comparing IBD hospital admission rates between patients with and without HBV infection
Time frame: through study completion, an average of 6 month
number of IBD patients undergoing surgical treatment
comparing surgical treatment rates (intestinal resection in CD patients and total proctocolectomy in UC patients) for IBD between patients with and without HBV infection
Time frame: through study completion, an average of 6 month
Disease flares rates in IBD patients
comparing IBD disease flare rate between patients with and without HBV infection.
Time frame: through study completion, an average of 6 months
mortality rates in IBD patients
comparing IBD mortality rates between patients with and without HBV infection.
Time frame: through study completion, an average of 6 months
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