The purpose of this study is to determine if a low glycemic diet and lower-body electrical stimulation can reduce postprandial hypotension in individuals with chronic spinal cord injury.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
13
Low glycemic load diet
Lower-body electrical stimulation exercise for 1-h after eating
High glycemic load diet
Dodd Rehabilitation Hospital
Columbus, Ohio, United States
RECRUITINGMagnitude of systolic blood pressure decrease (in-lab)
Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast and lunch under laboratory-controlled conditions
Time frame: Visit 2-4, Day 1
Magnitude of systolic blood pressure decrease (at-home)
Calculated as the maximum decrease in systolic blood pressure in the 2-h after eating breakfast, lunch, and dinner for 3-days during at-home testing
Time frame: Visits 2-4, Days 1-3
Postprandial glucose (in-lab)
Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.
Time frame: Visits 2-4, Day 1
Postprandial insulin (in-lab)
Blood samples will be obtained from an intravenous catheter at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.
Time frame: Visits 2-4, Day 1
Postprandial glucose (at-home)
A continuous glucose monitor will be used to measure glucose for 2-h after breakfast, lunch, and dinner for 3-days during at-home testing
Time frame: Visits 2-4, Day 1-3
Blood flow (in-lab)
Blood flow at the radial, brachial, popliteal and superior mesenteric arteries will be obtained using Doppler imaging at regular intervals after eating breakfast (3-h) and lunch (2-h) under laboratory controlled conditions.
Time frame: Visits 2-4, Day 1
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