Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies.
There is growing evidence pointing to close interactions between acute ischemic stroke (AIS) and heart diseases. Heart diseases may lead to AIS (heart-to-brain interactions), with many cardiac conditions have been proposed as potential sources of cerebral embolism, and studies have also shown that AIS can induce cardiac injury (brain-to-heart interactions), namely Stroke-Heart Syndrome. In addition, due to the commonly shared risk factors, AIS patients had a significantly higher frequency of coexisting prior known or unknown coronary heart disease (brain-and-heart interactions). These heart problems not only add complexity to the etiological diagnosis but also account for a great proportionate mortality in AIS patients with reperfusion therapy, which is the most effective treatment method for AIS. The interconnected and coexisting properties of AIS and heart diseases requires a comprehensive scheme to evaluate, prevent, and treat patients. Heart Evaluation of Acute ischemic stroke with Reperfusion Therapy (HEART) is a single-center observational registry evaluating the heart of patients hospitalized for acute ischemic stroke with reperfusion therapy. This registry aims to establish quantified risk stratification and prognostic models, as well as suggest effective diagnostic and therapeutic strategies. The clinical, laboratory and imaging information will be collected at the baseline. During an estimated 3-year follow-up, the diagnostic or monitoring procedures, treatment, functional status and new vascular events will be recorded by web-based patients' self-reports, investigators' regular telephone visits.
Study Type
OBSERVATIONAL
Enrollment
400
observational only- no intervention
The first affiliated hospital of soochow university
Suzhou, Jiangsu, China
RECRUITINGRate of Major Adverse Cardiovascular Events
cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina
Time frame: 1 year
Rate of Major Adverse Cardiovascular Events
ardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina
Time frame: 90 days
Functional Outcome
Percentage of patients with modified Rankin Scale (mRS) scores (minimum 0 and maximum 5) 3 to 5, who are considered to be disabled.
Time frame: 90 days
Rate of Ischemic Stroke
fatal and nonfatal ischemic stroke.
Time frame: 1 year
Rate of Acute Coronary Syndrome
fatal and nonfatal myocardial infarction and unstable angina
Time frame: 1 year
Rate of Cardiovascular Mortality
any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death
Time frame: 1 year
Time to First Major Adverse Cardiovascular Event
from the date of enrollment until the date of first documented cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction or unstable angina, whichever comes first, assessed up to 3 years
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Time frame: 3 years
Time to First Ischemic Stroke
from the date of enrollment until the date of first documented ischemic stroke, assessed up to 3 years
Time frame: 3 years
Rate of Major Adverse Cardiovascular Events
cardiovascular mortality (any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death), ischemic stroke, myocardial infarction and unstable angina
Time frame: 3 years
Rate of Ischemic Stroke
fatal and nonfatal ischemic stroke
Time frame: 3 years
Rate of Acute Coronary Syndrome
fatal and nonfatal myocardial infarction and unstable angina
Time frame: 3 years
Rate of Cardiovascular Mortality
any mortality due to ischemic stroke, myocardial infarction, other cardiac diseases, or unobserved sudden death
Time frame: 3 years