Study of Placental Inflammation in Gestational Diabetes

Fondazione Policlinico Universitario Agostino Gemelli IRCCS40 enrolled

Overview

The aim of this study is to investigate the placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6

The aim of this study is to investigate systemic and placental inflammation in women with gestational diabetes mellitus, in particular the role of inflammasome NLRP3 and the chemokine scavenger decoy receptor D6, compared to women with uncomplicated pregnancy

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Gestational Diabetes Mellitus (GDM)

Interventions

Blood samples for inflammatory markersOTHER

Blood sampling

Placental ExtractOTHER

Placental sampling after caesarean section

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Women with gestational diabetes mellitus * Women with uncomplicated pregnancy * Age \>18 years * Singleton pregnancy Exclusion Criteria: * Age \< 18 years * Infections (HIV,HCV) * Multiple pregnancy * Cancer

Locations (1)

Fondazione Policlinico Universitario Agostino Gemelli

Rome, Italy

Outcomes

Primary Outcomes

Placental inflammation

Analysis of protein expression of inflammasome NLRP3 and D6 scavenger receptor in placental tissue.

Time frame: At delivery/birth

Data from ClinicalTrials.gov

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