PRP & PDO Threads in Treatment of Stress Incontinence

Al-Azhar University10 enrolled

Overview

The study will include 10 women with pure or predominant SUI symptoms, with severe urodynamic stress incontinence on urodynamics defined as loss of urine with sudden increases in abdominal pressure: eg, coughing, sneezing, or laughing). This will be conducted at the Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University. The purpose of study is to evaluate the efficacy and safety of platelets rich plasma combined with PDO threads in the treatment of stress incontinence in Egyptian women.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Stress Incontinence, Female

Interventions

platelets rich plasma combined with PDO threadsPROCEDURE

1. Injections of platelets-rich plasma in the Anterior Vaginal Wall. 2. PDO thread placement in the paraurethral, lateral urethrovaginal, and suburethral areas

Eligibility

Sex: FEMALEMin age: 20 YearsMax age: 45 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Nonpregnant Women with SUI * Age between 20 to 45 years * Patients had a history of failed conservative treatment * Patients were on the waiting list for surgical treatment of SUI Exclusion Criteria: * Under anti-platelet agent treatment * Under NSAIDs * Platelet dysfunction syndrome * Critical thrombocytopenia * Hypofibrionogenaemia * Sepsis * Acute and chronic infections * Chronic liver disease * Anti-coagulation therapy * History of malignancy * Pregnancy * history of active malignant pathology * mental disorders making them unable to give consent * genitourinary fistula * pelvic organs prolapse stage \>2 according to the Pelvic Organ Prolapse Quantification system, and detrusor overactivity on urodynamics.

Locations (1)

Department of Obstetrics and Gynecology, Faculty of Medicine, Al-Azhar University.

Cairo, Egypt

RECRUITING

Outcomes

Primary Outcomes

evaluation of reported SUI symptoms

subjective evaluation of reported SUI symptoms, indicated by the patient's response to question of the ICIQ-FLUTS questionnaire: "Does urine leak when you are physically active, exert yourself, cough or sneeze?"

Time frame: After 4 months

Data from ClinicalTrials.gov

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